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Literature summary for 3.5.2.6 extracted from
- Inhibition of serine beta -lactamases by vanadate-catechol complexes (2008), Biochemistry, 47, 9467-9474.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | inhibition by vanadate-catechol complex. 0.1 mM vanadate, varied catechol; vanadate alone (to 1.0 mM) and catechol alone (to 2.0 mM) do not inhibit. Compounds that afford no inhibition are 2,3-dihydroxybenzoic acid, 2,3-dihydroxypyridine (3-hydroxypyrid-2-one), cis-1,2-dihydroxycyclohexane, and L-mandelic acid | Enterobacter cloacae | |
| additional information | inhibition by vanadate-catechol complex. 0.1 mM vanadate, varied catechol; vanadate alone (to 1.0 mM) and catechol alone (to 2.0 mM) do not inhibit. Compounds that afford no inhibition are 2,3-dihydroxybenzoic acid, 2,3-dihydroxypyridine (3-hydroxypyrid-2-one), cis-1,2-dihydroxycyclohexane, and L-mandelic acid | Escherichia coli | |
| vanadate/(3,4-dihydroxyphenyl)methanaminium complex | competitive inhibition, 1:1 complexes of vanadate with a variety of catechols | Enterobacter cloacae |  |
| vanadate/(3,4-dihydroxyphenyl)methanaminium complex | competitive inhibition, 1:1 complexes of vanadate with a variety of catechols | Escherichia coli | |
| vanadate/2,3,5,6-tetrahydroxycyclohexa-2,5-diene-1,4-dione complex | competitive inhibition, 1:1 complexes of vanadate with a variety of catechols | Enterobacter cloacae | |
| vanadate/2,3,5,6-tetrahydroxycyclohexa-2,5-diene-1,4-dione complex | competitive inhibition, 1:1 complexes of vanadate with a variety of catechols | Escherichia coli | |
| vanadate/2,3-dihydroxynaphthalene-1,4-dione complex | competitive inhibition, 1:1 complexes of vanadate with a variety of catechols | Enterobacter cloacae | |
| vanadate/2,3-dihydroxynaphthalene-1,4-dione complex | competitive inhibition, 1:1 complexes of vanadate with a variety of catechols | Escherichia coli | |
| vanadate/2-(3,4-dihydroxyphenyl)acetate complex | competitive inhibition, 1:1 complexes of vanadate with a variety of catechols | Enterobacter cloacae | |
| vanadate/2-(3,4-dihydroxyphenyl)acetate complex | competitive inhibition, 1:1 complexes of vanadate with a variety of catechols | Escherichia coli | |
| vanadate/2-methoxyphenol complex | competitive inhibition, 1:1 complexes of vanadate with a variety of catechols | Enterobacter cloacae | |
| vanadate/2-methoxyphenol complex | competitive inhibition, 1:1 complexes of vanadate with a variety of catechols | Escherichia coli | |
| vanadate/3,4,5,6-tetrafluorobenzene-1,2-diol complex | competitive inhibition, 1:1 complexes of vanadate with a variety of catechols | Enterobacter cloacae | |
| vanadate/3,4,5,6-tetrafluorobenzene-1,2-diol complex | competitive inhibition, 1:1 complexes of vanadate with a variety of catechols | Escherichia coli | |
| vanadate/3,4-dihydroxybenzoate complex | competitive inhibition, 1:1 complexes of vanadate with a variety of catechols | Enterobacter cloacae | |
| vanadate/3,4-dihydroxybenzoate complex | competitive inhibition, 1:1 complexes of vanadate with a variety of catechols | Escherichia coli | |
| vanadate/3-phenylcatechol complex | competitive inhibition, 1:1 complexes of vanadate with a variety of catechols, most effective | Enterobacter cloacae | |
| vanadate/3-phenylcatechol complex | competitive inhibition, 1:1 complexes of vanadate with a variety of catechols, most effective | Escherichia coli | |
| vanadate/4-nitrobenzene-1,2-diol complex | competitive inhibition, 1:1 complexes of vanadate with a variety of catechols | Enterobacter cloacae | |
| vanadate/4-nitrobenzene-1,2-diol complex | competitive inhibition, 1:1 complexes of vanadate with a variety of catechols | Escherichia coli | |
| vanadate/biphenyl-3,4-diol complex | competitive inhibition, 1:1 complexes of vanadate with a variety of catechols | Enterobacter cloacae | |
| vanadate/biphenyl-3,4-diol complex | competitive inhibition, 1:1 complexes of vanadate with a variety of catechols | Escherichia coli | |
| vanadate/naphthalene-1,2-diol complex | competitive inhibition, 1:1 complexes of vanadate with a variety of catechols | Enterobacter cloacae | |
| vanadate/naphthalene-1,2-diol complex | competitive inhibition, 1:1 complexes of vanadate with a variety of catechols | Escherichia coli | |
| vanadate/naphthalene-2,3-diol complex | competitive inhibition, 1:1 complexes of vanadate with a variety of catechols | Enterobacter cloacae | |
| vanadate/naphthalene-2,3-diol complex | competitive inhibition, 1:1 complexes of vanadate with a variety of catechols | Escherichia coli | |
| vanadate/phenol complex | competitive inhibition, 1:1 complexes of vanadate with a variety of catechols | Enterobacter cloacae | |
| vanadate/phenol complex | competitive inhibition, 1:1 complexes of vanadate with a variety of catechols | Escherichia coli | |
| vanadate/pyrocatechol complex | competitive inhibition, 1:1 complexes of vanadate with a variety of catechols | Enterobacter cloacae | |
| vanadate/pyrocatechol complex | competitive inhibition, 1:1 complexes of vanadate with a variety of catechols | Escherichia coli | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Enterobacter cloacae | P05364 | P99 | - |
| Enterobacter cloacae P99 | P05364 | P99 | - |
| Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CENTA + H2O | - |
Escherichia coli | (2R)-5-{[(3-carboxy-4-nitrophenyl)sulfanyl]methyl}-2-{(R)-carboxy[2-(thiophen-2-yl)acetamido]methyl}-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
| CENTA + H2O | - |
Enterobacter cloacae | (2R)-5-{[(3-carboxy-4-nitrophenyl)sulfanyl]methyl}-2-{(R)-carboxy[2-(thiophen-2-yl)acetamido]methyl}-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
| CENTA + H2O | - |
Enterobacter cloacae P99 | (2R)-5-{[(3-carboxy-4-nitrophenyl)sulfanyl]methyl}-2-{(R)-carboxy[2-(thiophen-2-yl)acetamido]methyl}-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| class A TEM-2 beta-lactamase | - |
Escherichia coli |
| class C beta-lactamase | - |
Enterobacter cloacae |
| oxa-1 beta-lactamase | - |
Escherichia coli |
| serine beta-lactamase | - |
Enterobacter cloacae |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00043 | - |
vanadate/3-phenylcatechol complex | most effective, pH 7.0, 25°C | Enterobacter cloacae | |
| 0.00051 | - |
vanadate/4-nitrobenzene-1,2-diol complex | pH 7.0, 25°C | Enterobacter cloacae | |
| 0.00058 | - |
vanadate/naphthalene-2,3-diol complex | pH 7.0, 25°C | Enterobacter cloacae | |
| 0.00065 | - |
vanadate/2,3-dihydroxynaphthalene-1,4-dione complex | pH 7.0, 25°C | Enterobacter cloacae | |
| 0.00086 | - |
vanadate/naphthalene-1,2-diol complex | pH 7.0, 25°C | Enterobacter cloacae | |
| 0.0009 | - |
vanadate/biphenyl-3,4-diol complex | pH 7.0, 25°C | Enterobacter cloacae | |
| 0.0011 | - |
vanadate/biphenyl-3,4-diol complex | pH 7.0, 25°C | Escherichia coli | |
| 0.0015 | - |
vanadate/pyrocatechol complex | pH 7.0, 25°C | Escherichia coli | |
| 0.0019 | - |
vanadate/3,4,5,6-tetrafluorobenzene-1,2-diol complex | pH 7.0, 25°C | Enterobacter cloacae | |
| 0.0027 | - |
vanadate/pyrocatechol complex | pH 7.0, 25°C | Enterobacter cloacae | |
| 0.003 | - |
vanadate/3-phenylcatechol complex | most effective, pH 7.0, 25°C | Escherichia coli | |
| 0.0042 | - |
vanadate/2-(3,4-dihydroxyphenyl)acetate complex | pH 7.0, 25°C | Enterobacter cloacae | |
| 0.0057 | - |
vanadate/3,4-dihydroxybenzoate complex | pH 7.0, 25°C | Enterobacter cloacae | |
| 0.01 | - |
vanadate/2,3,5,6-tetrahydroxycyclohexa-2,5-diene-1,4-dione complex | pH 7.0, 25°C | Enterobacter cloacae | |
| 0.0109 | - |
vanadate/(3,4-dihydroxyphenyl)methanaminium complex | pH 7.0, 25°C | Enterobacter cloacae | |
| 0.016 | - |
vanadate/naphthalene-2,3-diol complex | pH 7.0, 25°C | Escherichia coli | |
| 0.023 | - |
vanadate/3-phenylcatechol complex | most effective, pH 7.0, 25°C | Escherichia coli | |
| 0.03 | - |
vanadate/biphenyl-3,4-diol complex | pH 7.0, 25°C | Escherichia coli | |
| 0.045 | - |
vanadate/(3,4-dihydroxyphenyl)methanaminium complex | pH 7.0, 25°C | Escherichia coli | |
| 0.05 | - |
vanadate/2-methoxyphenol complex | pH 7.0, 25°C | Enterobacter cloacae | |
| 0.062 | - |
vanadate/pyrocatechol complex | pH 7.0, 25°C | Escherichia coli | |
| 0.077 | - |
vanadate/naphthalene-2,3-diol complex | pH 7.0, 25°C | Escherichia coli | |
| 0.14 | - |
vanadate/2-(3,4-dihydroxyphenyl)acetate complex | pH 7.0, 25°C | Escherichia coli | |
| 0.16 | - |
vanadate/4-nitrobenzene-1,2-diol complex | pH 7.0, 25°C | Escherichia coli | |
| 0.2 | - |
vanadate/3,4-dihydroxybenzoate complex | pH 7.0, 25°C | Escherichia coli | |
| 0.22 | - |
vanadate/phenol complex | pH 7.0, 25°C | Enterobacter cloacae | |
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