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Literature summary for 3.5.2.6 extracted from

  • Jin, W.; Arakawa, Y.; Yasuzawa, H.; Taki, T.; Hashiguchi, R.; Mitsutani, K.; Shoga, A.; Yamaguchi, Y.; Kurosaki, H.; Shibata, N.; Ohta, M.; Goto, M.
    Comparative study of the inhibition of metallo-beta-lactamases (IMP-1 and VIM-2) by thiol compounds that contain a hydrophobic group (2004), Biol. Pharm. Bull., 27, 851-856.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Pseudomonas aeruginosa
expression in Escherichia coli Serratia marcescens

Inhibitors

Inhibitors Comment Organism Structure
2-(mercaptomethyl)-4-phenylbutanoic acid IC50: 0.0026 mM Pseudomonas aeruginosa
2-(mercaptomethyl)-4-phenylbutanoic acid IC50: 0.0074 mM Serratia marcescens
2-(mercaptomethyl)-5-phenylpentanoic acid IC50: 0.0013 mM Pseudomonas aeruginosa
2-(mercaptomethyl)-5-phenylpentanoic acid IC50: 0.0097 mM Serratia marcescens
2-(mercaptomethyl)-6-phenylhexanoic acid IC50: 0.0011 mM Pseudomonas aeruginosa
2-(mercaptomethyl)-6-phenylhexanoic acid IC50: 0.0012 mM Serratia marcescens
2-benzyl-3-mercaptopropanoic acid IC50: 0.0143 mM Pseudomonas aeruginosa
2-benzyl-3-mercaptopropanoic acid IC50: 0.0164 mM Serratia marcescens
N-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-3-mercapto-propionamide IC50: 0.0063 mM Pseudomonas aeruginosa
N-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-3-mercapto-propionamide IC50: 0.0142 mM Serratia marcescens
N-[3-(7-chloro-quinolin-4-ylamino)-propyl]-3-mercapto-propionamide IC50: 0.0065 mM Pseudomonas aeruginosa
N-[3-(7-chloro-quinolin-4-ylamino)-propyl]-3-mercapto-propionamide IC50: 0.0066 mM Serratia marcescens
N-[4-(7-chloro-quinolin-4-ylamino)-butyl]-3-mercapto-propionamide IC50: 0.0024 mM Pseudomonas aeruginosa
N-[4-(7-chloro-quinolin-4-ylamino)-butyl]-3-mercapto-propionamide IC50: 0.0025 mM Serratia marcescens
N-[5-(7-chloro-quinolin-4-ylamino)-pentyl]-3-mercapto-propionamide IC50: 0.0076 mM Pseudomonas aeruginosa
N-[5-(7-chloro-quinolin-4-ylamino)-pentyl]-3-mercapto-propionamide IC50: 0.0067 mM Serratia marcescens
N-[6-(7-cloro-quinolin-4-ylamino)-hexyl]-3-mercapto-propionamide IC50: 0.0049 mM Pseudomonas aeruginosa
N-[6-(7-cloro-quinolin-4-ylamino)-hexyl]-3-mercapto-propionamide IC50: 0.0034 mM Serratia marcescens

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
-
-
-
Serratia marcescens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Pseudomonas aeruginosa
-
Serratia marcescens

Synonyms

Synonyms Comment Organism
metallo-beta-lactamase IMP-1
-
Serratia marcescens
metallo-beta-lactamase VIM-2
-
Pseudomonas aeruginosa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0011
-
IC50: 0.0011 mM Pseudomonas aeruginosa 2-(mercaptomethyl)-6-phenylhexanoic acid
0.0012
-
IC50: 0.0012 mM Serratia marcescens 2-(mercaptomethyl)-6-phenylhexanoic acid
0.0013
-
IC50: 0.0013 mM Pseudomonas aeruginosa 2-(mercaptomethyl)-5-phenylpentanoic acid
0.0024
-
IC50: 0.0024 mM Pseudomonas aeruginosa N-[4-(7-chloro-quinolin-4-ylamino)-butyl]-3-mercapto-propionamide
0.0025
-
IC50: 0.0025 mM Serratia marcescens N-[4-(7-chloro-quinolin-4-ylamino)-butyl]-3-mercapto-propionamide
0.0026
-
IC50: 0.0026 mM Pseudomonas aeruginosa 2-(mercaptomethyl)-4-phenylbutanoic acid
0.0034
-
IC50: 0.0034 mM Serratia marcescens N-[6-(7-cloro-quinolin-4-ylamino)-hexyl]-3-mercapto-propionamide
0.0049
-
IC50: 0.0049 mM Pseudomonas aeruginosa N-[6-(7-cloro-quinolin-4-ylamino)-hexyl]-3-mercapto-propionamide
0.0063
-
IC50: 0.0063 mM Pseudomonas aeruginosa N-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-3-mercapto-propionamide
0.0065
-
IC50: 0.0065 mM Pseudomonas aeruginosa N-[3-(7-chloro-quinolin-4-ylamino)-propyl]-3-mercapto-propionamide
0.0066
-
IC50: 0.0066 mM Serratia marcescens N-[3-(7-chloro-quinolin-4-ylamino)-propyl]-3-mercapto-propionamide
0.0067
-
IC50: 0.0067 mM Serratia marcescens N-[5-(7-chloro-quinolin-4-ylamino)-pentyl]-3-mercapto-propionamide
0.0074
-
IC50: 0.0074 mM Serratia marcescens 2-(mercaptomethyl)-4-phenylbutanoic acid
0.0076
-
IC50: 0.0076 mM Pseudomonas aeruginosa N-[5-(7-chloro-quinolin-4-ylamino)-pentyl]-3-mercapto-propionamide
0.0097
-
IC50: 0.0097 mM Serratia marcescens 2-(mercaptomethyl)-5-phenylpentanoic acid
0.0142
-
IC50: 0.0142 mM Serratia marcescens N-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-3-mercapto-propionamide
0.0143
-
IC50: 0.0143 mM Pseudomonas aeruginosa 2-benzyl-3-mercaptopropanoic acid
0.0164
-
IC50: 0.0164 mM Serratia marcescens 2-benzyl-3-mercaptopropanoic acid