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Literature summary for 3.5.2.6 extracted from

  • Castanheira, M.; Toleman, M.A.; Jones, R.N.; Schmidt, F.J.; Walsh, T.R.
    Molecular characterization of a beta-lactamase gene, blaGIM-1, encoding a new subclass of metallo-beta-lactamase (2004), Antimicrob. Agents Chemother., 48, 4654-4661.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.2.6

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.004
-
 cefotaxime 25°C, pH 7.0 Pseudomonas aeruginosa
0.007
-
 cefuroxime 25°C, pH 7.0 Pseudomonas aeruginosa
0.012
-
 nitrocefin 25°C, pH 7.0 Pseudomonas aeruginosa
0.02
-
 ampicillin 25°C, pH 7.0 Pseudomonas aeruginosa
0.022
-
 cephalothin 25°C, pH 7.0 Pseudomonas aeruginosa
0.025
-
 meropenem 25°C, pH 7.0 Pseudomonas aeruginosa
0.031
-
 ceftazidime 25°C, pH 7.0 Pseudomonas aeruginosa
0.046
-
 penicillin 25°C, pH 7.0 Pseudomonas aeruginosa
0.057
-
 ticarcillin 25°C, pH 7.0 Pseudomonas aeruginosa
0.069
-
 piperacillin 25°C, pH 7.0 Pseudomonas aeruginosa
0.17
-
 carbenicillin 25°C, pH 7.0 Pseudomonas aeruginosa
0.206
-
 cefoxitin 25°C, pH 7.0 Pseudomonas aeruginosa
0.287
-
 Imipenem 25°C, pH 7.0 Pseudomonas aeruginosa
0.431
-
 cefepime 25°C, pH 7.0 Pseudomonas aeruginosa
1.035
-
 moxalactam 25°C, pH 7.0 Pseudomonas aeruginosa

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa Q704U4
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Pseudomonas aeruginosa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a penicillin + H2O
-
 Pseudomonas aeruginosa a penicilloic acid
-
 ?
ampicillin + H2O
-
 Pseudomonas aeruginosa (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
carbenicillin + H2O
-
 Pseudomonas aeruginosa (2R,4S)-2-{(R)-carboxy[2-carboxy(phenyl)acetamido]methyl}-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
cefepime + H2O
-
 Pseudomonas aeruginosa (2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-5-[(1-methylpyrrolidinium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
cefotaxime + H2O
-
 Pseudomonas aeruginosa (2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
cefoxitin + H2O
-
 Pseudomonas aeruginosa (2R)-5-[(carbamoyloxy)methyl]-2-[(S)-carboxy(methoxy)[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
ceftazidime + H2O
-
 Pseudomonas aeruginosa (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}(carboxy)methyl]-5-[(pyridin-1-ium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
cefuroxime + H2O
-
 Pseudomonas aeruginosa (2R)-5-[(carbamoyloxy)methyl]-2-[(R)-carboxy{[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
cephalothin + H2O
-
 Pseudomonas aeruginosa (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
imipenem + H2O
-
 Pseudomonas aeruginosa (5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
 ?
meropenem + H2O
-
 Pseudomonas aeruginosa (4R,5S)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
 ?
moxalactam + H2O
-
 Pseudomonas aeruginosa (2R)-2-{(R)-carboxy[2-carboxy(4-hydroxyphenyl)acetamido]methoxymethyl}-5-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-3,6-dihydro-2H-1,3-oxazine-4-carboxylic acid
-
 ?
nitrocefin + H2O
-
 Pseudomonas aeruginosa (2R)-2-{(R)-carboxy[2-(thiophen-2-yl)acetamido]methyl}-5-[(E)-2-(2,4-dinitrophenyl)ethenyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
penicillin + H2O
-
 Pseudomonas aeruginosa ?
-
 ?
piperacillin + H2O
-
 Pseudomonas aeruginosa (2R,4S)-2-[(R)-carboxy[[(2R)-2-[[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino]-2-phenylacetyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
ticarcillin + H2O
-
 Pseudomonas aeruginosa (2R,4S)-2-[(R)-carboxy[[(2R)-2-carboxy-2-(thiophen-3-yl)acetyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?

Synonyms

Synonyms Comment Organism
GIM-1
-
 Pseudomonas aeruginosa

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1
-
 cefotaxime 25°C, pH 7.0 Pseudomonas aeruginosa
2.3
-
 ticarcillin 25°C, pH 7.0 Pseudomonas aeruginosa
2.7
-
 meropenem 25°C, pH 7.0 Pseudomonas aeruginosa
3.3
-
 ampicillin 25°C, pH 7.0 Pseudomonas aeruginosa
4.1
-
 carbenicillin 25°C, pH 7.0 Pseudomonas aeruginosa
5.8
-
 nitrocefin 25°C, pH 7.0 Pseudomonas aeruginosa
5.9
-
 cefuroxime 25°C, pH 7.0 Pseudomonas aeruginosa
6.6
-
 penicillin 25°C, pH 7.0 Pseudomonas aeruginosa
6.9
-
 piperacillin 25°C, pH 7.0 Pseudomonas aeruginosa
8.3
-
 cefoxitin 25°C, pH 7.0 Pseudomonas aeruginosa
14
-
 moxalactam 25°C, pH 7.0 Pseudomonas aeruginosa
16
-
 cephalothin 25°C, pH 7.0 Pseudomonas aeruginosa
17
-
 cefepime 25°C, pH 7.0 Pseudomonas aeruginosa
18
-
 ceftazidime 25°C, pH 7.0 Pseudomonas aeruginosa
27
-
 Imipenem 25°C, pH 7.0 Pseudomonas aeruginosa

pI Value

Organism Comment pI Value Maximum pI Value
Pseudomonas aeruginosa isoelectric focusing, pH-range 3-10
-
 5.4