Literature summary for 3.5.2.5 extracted from

Guzman, K.; Badia, J.; Gimenez, R.; Aguilar, J.; Baldoma, L.
Transcriptional regulation of the gene cluster encoding allantoinase and guanine deaminase in Klebsiella pneumoniae (2011), J. Bacteriol., 193, 2197-2207.

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Organism

Organism	UniProt	Comment	Textmining
Klebsiella pneumoniae	-	-	-

Expression

Organism	Comment	Expression
Klebsiella pneumoniae	the genes involved in the conversion of allantoin into allantoate and in the deamination of guanine to xanthine are organized in three transcriptional units, hpxSAB, hpxC, and guaD. hpxSAB, which includes hpxB encoding allantoinase, is the most tightly regulated unit. This operon is activated by growth on allantoin as a nitrogen source. Addition of allantoin to nitrogen excess cultures does not result in hpxSAB induction. Full induction of hpxSAB by allantoin requires both HpxS, encoding a regulatory protein of the GntR family, and nitrogen assimilation control protein NAC	up

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Release 2023.1 (January 2023)