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Literature summary for 3.5.1.99 extracted from

  • Dahlhaus, H.; Hanekamp, W.; Lehr, M.
    (Indolylalkyl)piperidine carbamates as inhibitors of fatty acid amide hydrolase (FAAH) (2017), MedChemComm, 8, 616-620 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
3'-carbamoyl[1,1'-biphenyl]-3-yl cyclohexylcarbamate
-
Rattus norvegicus
phenyl 4-[(1H-indol-1-yl)methyl]piperidine-1-carboxylate
-
Rattus norvegicus
phenyl 4-[2-(1H-indol-1-yl)ethyl]piperidine-1-carboxylate
-
Rattus norvegicus
phenyl 4-[2-(4-fluoro-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
-
Rattus norvegicus
phenyl 4-[2-(5-chloro-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
-
Rattus norvegicus
phenyl 4-[2-(5-cyano-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
-
Rattus norvegicus
phenyl 4-[2-(5-fluoro-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
-
Rattus norvegicus
phenyl 4-[2-(5-methoxy-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
-
Rattus norvegicus
phenyl 4-[2-(5-methyl-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
-
Rattus norvegicus
phenyl 4-[2-(6-fluoro-1H-indol-1-yl)ethyl]piperazine-1-carboxylate
-
Rattus norvegicus
phenyl 4-[2-(6-fluoro-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
-
Rattus norvegicus
phenyl 4-[2-(7-fluoro-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
-
Rattus norvegicus
phenyl 4-[2-(9H-carbazol-9-yl)ethyl]piperidine-1-carboxylate
-
Rattus norvegicus
phenyl 4-[3-(1H-indol-1-yl)propyl]piperidine-1-carboxylate
-
Rattus norvegicus
phenyl 4-[4-(1H-indol-1-yl)butyl]piperidine-1-carboxylate
-
Rattus norvegicus
phenyl [4-(1H-indol-1-yl)butyl]carbamate
-
Rattus norvegicus
phenyl [5-(1H-indol-1-yl)pentyl]carbamate
-
Rattus norvegicus
phenyl [6-(1H-indol-1-yl)hexyl]carbamate
-
Rattus norvegicus
phenyl [7-(1H-indol-1-yl)heptyl]carbamate
-
Rattus norvegicus
phenyl [8-(1H-indol-1-yl)octyl]carbamate
-
Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P97612
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000046
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Rattus norvegicus phenyl 4-[2-(6-fluoro-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
0.000052
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Rattus norvegicus phenyl 4-[2-(7-fluoro-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
0.00006
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Rattus norvegicus 3'-carbamoyl[1,1'-biphenyl]-3-yl cyclohexylcarbamate
0.000093
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Rattus norvegicus phenyl [7-(1H-indol-1-yl)heptyl]carbamate
0.000094
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Rattus norvegicus phenyl [5-(1H-indol-1-yl)pentyl]carbamate
0.00011
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Rattus norvegicus phenyl 4-[2-(1H-indol-1-yl)ethyl]piperidine-1-carboxylate
0.00011
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Rattus norvegicus phenyl 4-[2-(4-fluoro-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
0.00013
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Rattus norvegicus phenyl 4-[2-(5-fluoro-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
0.00018
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Rattus norvegicus phenyl 4-[4-(1H-indol-1-yl)butyl]piperidine-1-carboxylate
0.00024
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Rattus norvegicus phenyl [8-(1H-indol-1-yl)octyl]carbamate
0.00025
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Rattus norvegicus phenyl [6-(1H-indol-1-yl)hexyl]carbamate
0.00036
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Rattus norvegicus phenyl 4-[2-(5-methoxy-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
0.00041
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Rattus norvegicus phenyl 4-[2-(5-chloro-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
0.00041
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Rattus norvegicus phenyl 4-[2-(9H-carbazol-9-yl)ethyl]piperidine-1-carboxylate
0.00057
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Rattus norvegicus phenyl 4-[3-(1H-indol-1-yl)propyl]piperidine-1-carboxylate
0.00074
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Rattus norvegicus phenyl 4-[2-(5-methyl-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
0.00081
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Rattus norvegicus phenyl 4-[2-(6-fluoro-1H-indol-1-yl)ethyl]piperazine-1-carboxylate
0.00096
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Rattus norvegicus phenyl [4-(1H-indol-1-yl)butyl]carbamate
0.00097
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Rattus norvegicus phenyl 4-[2-(5-cyano-1H-indol-1-yl)ethyl]piperidine-1-carboxylate
0.00987
-
37°C, pH 7.4, assay in brain microsomes, substrate N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide Rattus norvegicus phenyl 4-[(1H-indol-1-yl)methyl]piperidine-1-carboxylate