Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1-benzothiophen-6-ylamino)([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)methanone | - |
Homo sapiens | |
(dodecylamino)[[(E)-[1-[3-(thiophen-2-yl)phenyl]ethylidene]amino]oxy]methanone | - |
Homo sapiens | |
(phenylamino)[[(4-phenylcyclohexylidene)amino]oxy]methanone | - |
Homo sapiens | |
(phenylamino)[[(E)-[1-[3-(thiophen-2-yl)phenyl]ethylidene]amino]oxy]methanone | - |
Homo sapiens | |
(phenylamino)[[(E)-[1-[4-(thiophen-2-yl)phenyl]ethylidene]amino]oxy]methanone | - |
Homo sapiens | |
([(E)-[1-(2,2'-bithiophen-5-yl)ethylidene]amino]oxy)(naphthalen-1-ylamino)methanone | - |
Homo sapiens | |
([(E)-[1-(4-cyclohexylphenyl)ethylidene]amino]oxy)(naphthalen-1-ylamino)methanone | - |
Homo sapiens | |
([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)(diphenylamino)methanone | - |
Homo sapiens | |
([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)(naphthalen-1-ylamino)methanone | - |
Homo sapiens | |
([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)(phenylamino)methanone | - |
Homo sapiens | |
([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)(piperidin-1-yl)methanone | - |
Homo sapiens | |
([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)[(4-fluorophenyl)amino]methanone | - |
Homo sapiens | |
([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)[(4-methoxyphenyl)amino]methanone | - |
Homo sapiens | |
([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)[(5-phenylpentyl)amino]methanone | - |
Homo sapiens | |
([(E)-[1-(biphenyl-4-yl)ethylidene]amino]oxy)(dimethylamino)methanone | - |
Homo sapiens | |
([(E)-[1-(biphenyl-4-yl)ethylidene]amino]oxy)(naphthalen-1-ylamino)methanone | - |
Homo sapiens | |
([(E)-[1-(biphenyl-4-yl)ethylidene]amino]oxy)(phenylamino)methanone | - |
Homo sapiens | |
3'-[(1E)-N-[(phenylcarbamoyl)oxy]ethanimidoyl]biphenyl-3-carboxamide | - |
Homo sapiens | |
additional information | a series of oxime carbamates as non-competitive, reversible inhibitors, and show remarkable selectivity for FAAH over the other components of the endocannabinoid system | Homo sapiens | |
N-(phenylcarbamoyl)-3'-[(1E)-N-[(phenylcarbamoyl)oxy]ethanimidoyl]biphenyl-3-carboxamide | - |
Homo sapiens | |
piperidin-1-yl[[(E)-[1-[3-(thiophen-2-yl)phenyl]ethylidene]amino]oxy]methanone | - |
Homo sapiens | |
URB597 | - |
Homo sapiens | |
[[(E)-[1-[4-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl]ethylidene]amino]oxy](naphthalen-1-ylamino)methanone | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum membrane | - |
Homo sapiens | 5789 | - |
membrane | bound to intracellular membranes, mainly of the endoplasmic reticulum | Homo sapiens | 16020 | - |
microsome | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(9Z)-N-ethyloctadec-9-enamide + H2O | Homo sapiens | - |
oleic acid + ethanolamine | - |
? | |
anandamide + H2O | Homo sapiens | i.e. N-arachidonoyl ethanolamide | arachidonic acid + ethanolamine | - |
? | |
N-palmitoyl ethanolamine + H2O | Homo sapiens | - |
palmitic acid + ethanolamine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(9Z)-N-ethyloctadec-9-enamide + H2O | - |
Homo sapiens | oleic acid + ethanolamine | - |
? | |
anandamide + H2O | i.e. N-arachidonoyl ethanolamide | Homo sapiens | arachidonic acid + ethanolamine | - |
? | |
N-palmitoyl ethanolamine + H2O | - |
Homo sapiens | palmitic acid + ethanolamine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FAAH | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.4 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000038 | - |
(phenylamino)[[(E)-[1-[3-(thiophen-2-yl)phenyl]ethylidene]amino]oxy]methanone | pH 8.4, 37°C | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000008 | - |
pH 8.4, 37°C | Homo sapiens | (phenylamino)[[(E)-[1-[3-(thiophen-2-yl)phenyl]ethylidene]amino]oxy]methanone | |
0.00001 | - |
pH 8.4, 37°C | Homo sapiens | ([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)(naphthalen-1-ylamino)methanone | |
0.000017 | - |
pH 8.4, 37°C | Homo sapiens | ([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)[(4-fluorophenyl)amino]methanone | |
0.000028 | - |
pH 8.4, 37°C | Homo sapiens | ([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)[(4-methoxyphenyl)amino]methanone | |
0.000069 | - |
pH 8.4, 37°C | Homo sapiens | ([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)(phenylamino)methanone | |
0.000084 | - |
pH 8.4, 37°C | Homo sapiens | 3'-[(1E)-N-[(phenylcarbamoyl)oxy]ethanimidoyl]biphenyl-3-carboxamide | |
0.0001 | - |
pH 8.4, 37°C | Homo sapiens | ([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)[(5-phenylpentyl)amino]methanone | |
0.000112 | - |
pH 8.4, 37°C | Homo sapiens | piperidin-1-yl[[(E)-[1-[3-(thiophen-2-yl)phenyl]ethylidene]amino]oxy]methanone | |
0.000116 | - |
pH 8.4, 37°C | Homo sapiens | (dodecylamino)[[(E)-[1-[3-(thiophen-2-yl)phenyl]ethylidene]amino]oxy]methanone | |
0.0002 | - |
pH 8.4, 37°C | Homo sapiens | (phenylamino)[[(E)-[1-[4-(thiophen-2-yl)phenyl]ethylidene]amino]oxy]methanone | |
0.00022 | - |
pH 8.4, 37°C | Homo sapiens | ([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)(piperidin-1-yl)methanone | |
0.000232 | - |
pH 8.4, 37°C | Homo sapiens | (1-benzothiophen-6-ylamino)([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)methanone | |
0.000401 | - |
pH 8.4, 37°C | Homo sapiens | ([(E)-[1-(biphenyl-4-yl)ethylidene]amino]oxy)(naphthalen-1-ylamino)methanone | |
0.00076 | - |
pH 8.4, 37°C | Homo sapiens | ([(E)-[1-(biphenyl-4-yl)ethylidene]amino]oxy)(phenylamino)methanone | |
0.001 | - |
pH 8.4, 37°C | Homo sapiens | ([(E)-[1-(4-cyclohexylphenyl)ethylidene]amino]oxy)(naphthalen-1-ylamino)methanone | |
0.001 | - |
pH 8.4, 37°C | Homo sapiens | [[(E)-[1-[4-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl]ethylidene]amino]oxy](naphthalen-1-ylamino)methanone | |
0.001 | - |
pH 8.4, 37°C | Homo sapiens | ([(E)-[1-(2,2'-bithiophen-5-yl)ethylidene]amino]oxy)(naphthalen-1-ylamino)methanone | |
0.025 | - |
pH 8.4, 37°C | Homo sapiens | N-(phenylcarbamoyl)-3'-[(1E)-N-[(phenylcarbamoyl)oxy]ethanimidoyl]biphenyl-3-carboxamide | |
0.05 | - |
pH 8.4, 37°C | Homo sapiens | ([(E)-[1-(biphenyl-3-yl)ethylidene]amino]oxy)(diphenylamino)methanone | |
0.05 | - |
pH 8.4, 37°C | Homo sapiens | ([(E)-[1-(biphenyl-4-yl)ethylidene]amino]oxy)(dimethylamino)methanone | |
0.05 | - |
pH 8.4, 37°C | Homo sapiens | (phenylamino)[[(4-phenylcyclohexylidene)amino]oxy]methanone |