Inhibitors | Comment | Organism | Structure |
---|---|---|---|
URB597 | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
anandamide + H2O | Rattus norvegicus | - |
arachidonic acid + ethanolamine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
adult male Wistar rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
dorsal root ganglion | L4 and L5 | Rattus norvegicus | - |
additional information | culturing does not induce major changes in FAAH expression in primary sensory neurons | Rattus norvegicus | - |
nerve | peripheral | Rattus norvegicus | - |
neuron | primary sensory, FAAH is localized in the soma, in small dorsal root ganglion neurons | Rattus norvegicus | - |
sciatic nerve | - |
Rattus norvegicus | - |
spinal cord | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
anandamide + H2O | - |
Rattus norvegicus | arachidonic acid + ethanolamine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
endocannabinoid-degrading enzyme | - |
Rattus norvegicus |
FAAH | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | injury to peripheral nerves induces changes in FAAH expression pattern in dorsal root ganglion, while inflammation of peripheral tissues does not induce changes in the FAAH expression pattern, overview | additional information |
General Information | Comment | Organism |
---|---|---|
physiological function | FAAH is a degradative enzyme for a group of endogenous signaling lipids that includes anandamide, that acts as an endocannabinoid and an endovanilloid by activating cannabinoid and vanilloid type 1 transient receptor potential,TRPV1, receptors, respectively, on dorsal root ganglion sensory neurons. Inhibition of FAAH activity increases anandamide concentrations in nervous tissue and reduces sensory hypersensitivity in animal pain models | Rattus norvegicus |