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Literature summary for 3.5.1.99 extracted from

  • Lang, W.; Qin, C.; Lin, S.; Khanolkar, A.D.; Goutopoulos, A.; Fan, P.; Abouzid, K.; Meng, Z.; Biegel, D.; Makriyannis, A.
    Substrate specificity and stereoselectivity of rat brain microsomal anandamide amidohydrolase (1999), J. Med. Chem., 42, 898-902.
    View publication on PubMed
Search for more literature for 3.5.1.99

Inhibitors

Inhibitors Comment Organism Structure
(6aR,10aR)-3-(1,1-dimethylheptyl)-9-(hydroxymethyl)-6,6-dimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol
-
 Rattus norvegicus
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-morpholin-4-yl-1H-pyrazole-3-carboxamide
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.34
-
 arachidonamide pH 7.4, 37°C Rattus norvegicus
2.78
-
 anandamide pH 7.4, 37°C Rattus norvegicus
7.31
-
 N-(o-hydroxyphenyl)arachidonamide pH 7.4, 37°C Rattus norvegicus
7.94
-
 (S)-alpha-methanandamide pH 7.4, 37°C Rattus norvegicus
33
-
 (R)-alpha-methanandamide pH 7.4, 37°C Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,8Z,11Z,14Z)-N-(2-fluoroethyl)icosa-5,8,11,14-tetraenamide + H2O hydrolysis rate is 1.3fold higher than the rate of anandamide hydrolysis Rattus norvegicus ?
-
 ?
(5Z,8Z,11Z,14Z)-N-(2-hydroxy-1,1-dimethylethyl)icosa-5,8,11,14-tetraenamide + H2O hydrolyzed at 4.3% the rate of anandamide Rattus norvegicus ?
-
 ?
(5Z,8Z,11Z,14Z)-N-(2-methylpropyl)icosa-5,8,11,14-tetraenamide + H2O hydrolyzed at 2% the rate of anandamide Rattus norvegicus ?
-
 ?
(5Z,8Z,11Z,14Z)-N-(3-hydroxyphenyl)icosa-5,8,11,14-tetraenamide + H2O hydrolysis rate is 1.5fold higher than the rate of anandamide hydrolysis Rattus norvegicus ?
-
 ?
(5Z,8Z,11Z,14Z)-N-(4-hydroxyphenyl)icosa-5,8,11,14-tetraenamide + H2O hydrolyzed at 16% the rate of anandamide Rattus norvegicus ?
-
 ?
(5Z,8Z,11Z,14Z)-N-tert-butylicosa-5,8,11,14-tetraenamide + H2O hydrolyzed at 1.8% the rate of anandamide Rattus norvegicus ?
-
 ?
(5Z,8Z,11Z,14Z)-N-[(1S)-1-methylpropyl]icosa-5,8,11,14-tetraenamide + H2O hydrolyzed at 6.3% the rate of anandamide Rattus norvegicus ?
-
 ?
(5Z,8Z,11Z,14Z)-N-[(2R)-2-hydroxypropyl]icosa-5,8,11,14-tetraenamide + H2O hydrolysis rate is 1.2fold higher than the rate of anandamide hydrolysis Rattus norvegicus ?
-
 ?
(5Z,8Z,11Z,14Z)-N-[(2S)-2-hydroxypropyl]icosa-5,8,11,14-tetraenamide + H2O hydrolyzed at 21% the rate of anandamide Rattus norvegicus ?
-
 ?
(9Z)-N-(2-hydroxyethyl)octadec-9-enamide + H2O hydrolyzed at 61% the rate of anandamide Rattus norvegicus ?
-
 ?
(9Z,12Z)-N-(2-hydroxyethyl)octadeca-9,12-dienamide + H2O hydrolyzed at 75% the rate of anandamide Rattus norvegicus ?
-
 ?
(9Z,12Z)-N-[(1R)-2-hydroxy-1-methylethyl]octadeca-9,12-dienamide + H2O hydrolyzed at 20.5% the rate of anandamide Rattus norvegicus ?
-
 ?
(R)-alpha-methanandamide + H2O 2.4% of the activity with anandamide Rattus norvegicus ?
-
 ?
(R)-beta-methanandamide + H2O 121% of the activity with anandamide Rattus norvegicus ?
-
 ?
(S)-alpha-methanandamide + H2O 23% of the activity with anandamide Rattus norvegicus ?
-
 ?
(S)-beta-methanandamide + H2O 21% of the activity with anandamide Rattus norvegicus ?
-
 ?
1-arachidonoylglycerol + H2O
-
 Rattus norvegicus ?
-
 ?
2-arachidonoylglycerol + H2O
-
 Rattus norvegicus ?
-
 ?
anandamide + H2O
-
 Rattus norvegicus ethanolamine + arachidonic acid
-
 ?
arachidonamide + H2O
-
 Rattus norvegicus arachidonic acid + NH3
-
 ?
beta-arachidonoylglycerol + H2O hydrolysis is 2.5fold higher than the rate of anandamide hydrolysis Rattus norvegicus ?
-
 ?
additional information N,N-bis(2-hydroxyethyl)arachidonamide is not hydrolyzed Rattus norvegicus ?
-
 ?
N-(2-hydroxyethyl)octadecanamide + H2O hydrolyzed at 15.0% the rate of anandamide Rattus norvegicus ?
-
 ?
N-(o-hydroxyphenyl)arachidonamide + H2O
-
 Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
AAH
-
 Rattus norvegicus
anandamide amidohydrolase
-
 Rattus norvegicus