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Literature summary for 3.5.1.99 extracted from

  • Wei, B.Q.; Mikkelsen, T.S.; McKinney, M.K.; Lander, E.S.; Cravatt, B.F.
    A second fatty acid amide hydrolase with variable distribution among placental mammals (2006), J. Biol. Chem., 281, 36569-36578.
    View publication on PubMed
Search for more literature for 3.5.1.99

Inhibitors

Inhibitors Comment Organism Structure
3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate
-
 Homo sapiens
3'-carbamoylbiphenyl-3-yl undec-10-yn-1-ylcarbamate
-
 Homo sapiens
4-(benzyloxy)phenyl butylcarbamate
-
 Homo sapiens
7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
 Homo sapiens
JP104
-
 Homo sapiens
OL-135
-
 Homo sapiens
URB532
-
 Homo sapiens
URB597
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane FAAH-2 is luminally orientated in the membrane Homo sapiens 16020
-
membrane FAAH-1 shows a predominantly cytoplasmic orientation in the membrane Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
anandamide + H2O Homo sapiens FAAH-1 plays a primary role in regulating endocannabinoid signaling ethanolamine + arachidonic acid
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O00519
-
-
Homo sapiens Q6GMR7
-
-
Mus musculus O08914
-
-
Rattus norvegicus P97612
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
heart highly expressed Homo sapiens
-
kidney
-
 Homo sapiens
-
liver
-
 Homo sapiens
-
lung
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
additional information no activity in brain, small intestine and testis Homo sapiens
-
additional information no activity in heart Homo sapiens
-
OVCAR-3 cell
-
 Homo sapiens
-
prostate
-
 Homo sapiens
-
small intestine
-
 Homo sapiens
-
testis
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
anandamide + H2O
-
 Homo sapiens ethanolamine + arachidonic acid
-
 ?
anandamide + H2O FAAH-1 plays a primary role in regulating endocannabinoid signaling Homo sapiens ethanolamine + arachidonic acid
-
 ?
anandamide + H2O 5% of the activity with oleamide Homo sapiens ethanolamine + arachidonic acid
-
 ?
additional information no activity with N-oleoyltaurine Homo sapiens ?
-
 ?
N-oleoylethanolamine + H2O 23% of the activity with oleamide Homo sapiens oleic acid + ethanolamine
-
 ?
N-oleoylethanolamine + H2O 33% of the activity with anandamide Homo sapiens oleic acid + ethanolamine
-
 ?
N-oleoyltaurine + H2O 4% of the activity with anandamide Homo sapiens taurine + oleic acid
-
 ?
N-palmitoylethanolamine + H2O 12% of the activity with anandamide Homo sapiens palmitic acid + ethanolamine
-
 ?
N-palmitoylethanolamine + H2O 2.3% of the activity with oleamide Homo sapiens palmitic acid + ethanolamine
-
 ?
oleamide + H2O
-
 Homo sapiens oleic acid + NH3
-
 ?
oleamide + H2O 57% of the activity with anandamide Homo sapiens oleic acid + NH3
-
 ?

Synonyms

Synonyms Comment Organism
FAAH-1
-
 Mus musculus
FAAH-1
-
 Rattus norvegicus
FAAH-1
-
 Homo sapiens
FAAH-2
-
 Homo sapiens
FAAH-2 FAAH-2 is an ancient gene present in primates, but not murids Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00000038
-
 pH 9.0, 37°C Homo sapiens 3'-carbamoylbiphenyl-3-yl undec-10-yn-1-ylcarbamate
0.000001
-
 pH 9.0, 37°C Homo sapiens JP104
0.0000134
-
 pH 9.0, 37°C Homo sapiens OL-135
0.000206
-
 pH 9.0, 37°C Homo sapiens 7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
0.000283
-
 pH 9.0, 37°C Homo sapiens 4-(benzyloxy)phenyl butylcarbamate
0.00136
-
 pH 9.0, 37°C Homo sapiens URB532