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Literature summary for 3.5.1.98 extracted from

  • Huang, J.; Barr, E.; Rudnick, D.A.
    Characterization of the regulation and function of zinc-dependent histone deacetylases during rodent liver regeneration (2013), Hepatology, 57, 1742-1751.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
suberoylanilide hydroxyamic acid a specific inhibitor of zinc-dependent histone deacetylase activity. The compound directly induces p19INK4d expression in regenerating liver by increasing p19INK4d promoter-associated histone acetylation, molecular mechanisms by which the inhibitor delays liver regeneration exerting promoter-specific effects on histone acetylation during liver regeneration, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm subcellular localization of the class II HDACs 4, 5, and 7 is regulated by phosphorylation-dependent shuttling between the cytoplasmic and nuclear compartments Mus musculus 5737
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nucleus isozymes HDACs 1 and 2 are exclusively localized in the nucleus Mus musculus 5634
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Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ zinc-dependent enzyme Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
liver
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 Mus musculus
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Synonyms

Synonyms Comment Organism
zinc-dependent histone deacetylase
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 Mus musculus
Zn-HDAC
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 Mus musculus

Expression

Organism Comment Expression
Mus musculus the hepatic enzyme activity is significantly increased in nuclear and cytoplasmic fractions following partial hepatectomy. Isoform-specific effects of partial hepatectomy on isozyme HDAC mRNA and protein expression, with increased isozyme expression of the class I HDACs, 1 and 8, and class II HDAC4 in regenerating liver. Hepatic expression of (class II) HDAC5 is unchanged after partial hepatectomy, HDAC5 exhibits transient nuclear accumulation in regenerating liver up

General Information

General Information Comment Organism
additional information isoform-specific regulation of zinc-dependent histone deacetylase expression, subcellular localization, and activity in regenerating liver. The signals that regulate the PH-induced metabolic response to hepatic insufficiency are not downstream, but might be upstream, of the target of suberoylanilide hydroxyamic acid's anti-regenerative activity Mus musculus
physiological function the enzyme activity promotes liver regeneration by regulating hepatocellular cell cycle progression at a step downstream of cyclin D1 induction Mus musculus