Literature summary for 3.5.1.98 extracted from

Chen, Y.; Huang, P.; Ai, W.; Li, X.; Guo, W.; Zhang, J.; Yang, J.
Histone deacetylase activity is decreased in peripheral blood monocytes in patients with COPD (2012), J. Inflamm., 9, 10.

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Application

Application	Comment	Organism
medicine	compared with healthy non-smokers, HDAC activity in the peripheral blood mononuclear cells of patients with chronic obstructive pulmonary disease is decreased by 40%. In patients with chronic obstructive pulmonary disease, HDAC activity is negatively correlated to smoke intensity. In chronic obstructive pulmonary disease patients who have smoked for more than 40 pack-years, HDAC activity in peripheral blood mononuclear cells is 40% lower than that in chronic obstructive pulmonary disease patients who have smoked fewer than 40 pack-years. Serum CXCL8 levels in patients with chronic obstructive pulmonary disease are significantly higher than that in controls and are negatively correlated to HDAC activities	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	patients with chronic obstructive pulmonary disease	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

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Release 2023.1 (January 2023)