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Literature summary for 3.5.1.98 extracted from

  • Smith, K.M.; Dobosy, J.R.; Reifsnyder, J.E.; Rountree, M.R.; Anderson, D.C.; Green, G.R.; Selker, E.U.
    H2B- and H3-specific histone deacetylases are required for DNA methylation in Neurospora crassa (2010), Genetics, 186, 1207-1216.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Neurospora crassa Q7RY64 isoform HDA-1
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Neurospora crassa Q7S8C9 isoform HDA-4
-
Neurospora crassa Q7SEB0 isoform HDA-3
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Neurospora crassa Q7SEL7 isoform HDA-2
-

Synonyms

Synonyms Comment Organism
HDA-1
-
 Neurospora crassa
HDA-2
-
 Neurospora crassa
HDA-3
-
 Neurospora crassa
HDA-4
-
 Neurospora crassa
RPD3
-
 Neurospora crassa

General Information

General Information Comment Organism
physiological function mutation of HDA-1 by repeat-induced point mutation causes partial loss of DNA methylation. The site-specific loss of DNA methylation in hda-1 correlates with loss of H3 lysine 9 trimethylation and increased H3 acetylation. In addition, an increase in H2B acetylation is observed by two-dimensional gel electrophoresis of histones of the hda-1 mutant Neurospora crassa
physiological function the hda-2 mutation does not affect DNA methylation at any region tested, and the deletion and repeat-induced point mutation alleles give identical results Neurospora crassa
physiological function the hda-3 mutation leads to global increases in histones H3 and H4 acetylation levels and to partial loss of DNA methylation Neurospora crassa
physiological function the hda-4 mutation leads to global increases in histones H3 and H4 acetylation levels Neurospora crassa