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Literature summary for 3.5.1.98 extracted from

  • Carneiro, K.; Donnet, C.; Rejtar, T.; Karger, B.; Barisone, G.; DÃaz, E.; Kortagere, S.; Lemire, J.; Levin, M.
    Histone deacetylase activity is necessary for left-right patterning during vertebrate development (2011), BMC Dev. Biol., 11, 29.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Xenopus laevis
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General Information

General Information Comment Organism
physiological function embryos injected with mRNA encoding a dominant-negative form of histone deacetylase lacked expression of gene Nodal related, Nr1, and exhibit randomized sidedness of the heart and viscera at stage 45. Pharmacological blockade of HDACs implicates cleavage stages as the active period. Inhibition during these early stages is correlated with an absence of Nr1 expression at stage 21, high levels of heterotaxia at stage 45, and the deposition of the epigenetic marker H3K4me2 on the Nr1 gene. The known HDAC partner protein Mad3 is a 5HT-binding regulator. While Mad3 overexpression leads to an absence of Nr1 transcription and randomizes the left-right axis, a mutant form of Mad3 lacking 5HT binding sites is not able to induce heterotaxia Xenopus laevis