Inhibitors | Comment | Organism | Structure |
---|---|---|---|
trichostatin A | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
chondrocyte | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
HDAC1 | - |
Homo sapiens |
HDAC2 | - |
Homo sapiens |
histone deacetylase 1 | - |
Homo sapiens |
histone deacetylase 2 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | HDAC1 and HDAC2 protein levels are elevated in chondrocytes from osteoarthritic patients | up |
General Information | Comment | Organism |
---|---|---|
malfunction | HDAC1 and HDAC2 with carboxy-terminal domains deleted, retain enzymatic activity but are unable to repress cartilage gene expression | Homo sapiens |
physiological function | HDAC1 and HDAC2 repress aggrecan and collagen 2(alpha1) expression but differ in their repression of collagen 9(alpha1), collagen 11(alpha1), dermatopontin, and cartilage oligomeric matrix protein. Carboxy-terminal domains of HDAC1 and HDAC2 are not required for enzymatic activity in vitro but are required for optimal deacetylation in vivo and repression of cartilage-specific gene expression | Homo sapiens |