Literature summary for 3.5.1.98 extracted from

Nian, H.; Bisson, W.H.; Dashwood, W.M.; Pinto, J.T.; Dashwood, R.H.
Alpha-keto acid metabolites of organoselenium compounds inhibit histone deacetylase activity in human colon cancer cells (2009), Carcinogenesis, 30, 1416-1423.

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Inhibitors

Inhibitors	Comment	Organism	Structure
alpha-keto-gamma-methylselenobutyrate	causes dose-dependent inhibition of HDAC activity, HDAC1 shows about 80% residual activity at 2 mM, HDAC8 shows less than 60% residual activity at 2 mM	Homo sapiens
beta-methylselenopyruvate	causes dose-dependent inhibition of HDAC activity, competitive inhibitor of HDAC8, HDAC1 shows about 30% residual activity at 2 mM, HDAC8 shows less than 30% residual activity at 2 mM	Homo sapiens
Butyrate	-	Homo sapiens
additional information	methylselenocysteine and selenomethionine have little or no inhibitory activity up to 2 mM	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleus	-	Homo sapiens	5634	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9BY41	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
colonic cancer cell	-	Homo sapiens	-
HCT-116 cell	-	Homo sapiens	-
HT-29 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N-acetyl-lysine-histone H3 + H2O	-	Homo sapiens	acetate + histone H3	-	?

Synonyms

Synonyms	Comment	Organism
HDAC1	-	Homo sapiens
HDAC8	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.02	-	HDAC8, at 37°C, pH not specified in the publication	Homo sapiens	beta-methylselenopyruvate

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Release 2023.1 (January 2023)