Literature summary for 3.5.1.98 extracted from

Zhuang, Y.; Nguyen, H.T.; Lasky, J.A.; Cao, S.; Li, C.; Hu, J.; Guo, X.; Burow, M.E.; Shan, B.
Requirement of a novel splicing variant of human histone deacetylase 6 for TGF-beta1-mediated gene activation (2010), Biochem. Biophys. Res. Commun., 392, 608-613.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Homo sapiens	5737	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
114000	-	truncated isoform of the HDAC6p114 protein, SDS-PAGE	Homo sapiens
131000	-	HDAC6p131, major isoform of histone deacetlyase 6, SDS-PAGE	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
alpha-tubulin + H2O	Homo sapiens	splicing variant HDAC6p114 is intact in its deacetylase activity against a-tubulin	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-549 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
alpha-tubulin + H2O	splicing variant HDAC6p114 is intact in its deacetylase activity against a-tubulin	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
HDAC6	-	Homo sapiens
HDAC6p114	splicing variant of histone deacetylase 6 lacking the first 152 amino acids from N-terminus in the major isoform HDAC6p131 protein	Homo sapiens
HDAC6p131	major isoform of histone deacetylase 6	Homo sapiens
histone deacetylase 6	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	HDAC6 mediates TGF-beta1-induced epithelial-mesenchymal transition in A-549 cells. Splicing variant HDAC6p114 is required for TGF-beta1-activated gene expression associated with epithelial-mesenchymal transition in A-549 cells	Homo sapiens

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Release 2023.1 (January 2023)