Application | Comment | Organism |
---|---|---|
medicine | HDAC inhibitors offer a promising strategy for cancer therapy | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2S)-8-oxo-2-[(3-piperidin-1-ylpropanoyl)amino]-N-quinolin-3-ylnonanamide | - |
Homo sapiens | |
1-methyl-N-[(1S)-7-oxo-1-[(4-phenyl-1,3-thiazol-2-yl)carbamoyl]octyl]piperidine-2-carboxamide | - |
Homo sapiens | |
2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo-1-(5-phenyl-1H-imidazol-2-yl)nonyl]acetamide | - |
Homo sapiens | |
2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo-1-(5-phenyl-1H-imidazol-2-yl)octyl]acetamide | - |
Homo sapiens | |
apicidin | - |
Homo sapiens | |
azumamide A | - |
Homo sapiens | |
azumamide E | - |
Homo sapiens | |
FK-228 | - |
Homo sapiens | |
FR235222 | - |
Homo sapiens | |
HC-toxin | - |
Homo sapiens | |
LBH-589 | - |
Homo sapiens | |
MGCD-0103 | - |
Homo sapiens | |
MS-275 | - |
Homo sapiens | |
N-[(1S)-1-(6-chloro-1H-benzimidazol-2-yl)-7-oxooctyl]-2-(5-methoxy-2-methyl-1H-indol-3-yl)acetamide | - |
Homo sapiens | |
PXD-101 | - |
Homo sapiens | |
vorinostat | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the acetylation status of lysine residues in nucleosomal proteins is tightly controlled by two counteracting enzyme families, the histone acetyl transferases and the histone deacetylases, HDACs | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-2780 cell | - |
Homo sapiens | - |
A-549 cell | - |
Homo sapiens | - |
G-401 cell | - |
Homo sapiens | - |
HCT-116 cell | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
renal epithelium cell line | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the acetylation status of lysine residues in nucleosomal proteins is tightly controlled by two counteracting enzyme families, the histone acetyl transferases and the histone deacetylases, HDACs | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HDAC | - |
Homo sapiens |
histone deacetylase | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000026 | - |
HDAC1 | Homo sapiens | 2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo-1-(5-phenyl-1H-imidazol-2-yl)nonyl]acetamide | |
0.00003 | - |
HDAC1 | Homo sapiens | vorinostat | |
0.000043 | - |
HDAC6 | Homo sapiens | vorinostat | |
0.000044 | - |
HDAC1 | Homo sapiens | apicidin | |
0.000048 | - |
HDAC3 | Homo sapiens | 2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo-1-(5-phenyl-1H-imidazol-2-yl)nonyl]acetamide | |
0.000055 | - |
HDAC1 | Homo sapiens | 1-methyl-N-[(1S)-7-oxo-1-[(4-phenyl-1,3-thiazol-2-yl)carbamoyl]octyl]piperidine-2-carboxamide | |
0.000057 | - |
HDAC3 | Homo sapiens | vorinostat | |
0.000059 | - |
HDAC1 | Homo sapiens | 2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo-1-(5-phenyl-1H-imidazol-2-yl)octyl]acetamide | |
0.000059 | - |
HDAC2 | Homo sapiens | 2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo-1-(5-phenyl-1H-imidazol-2-yl)nonyl]acetamide | |
0.000082 | - |
HDAC2 | Homo sapiens | vorinostat | |
0.00011 | - |
HDAC2 | Homo sapiens | 2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo-1-(5-phenyl-1H-imidazol-2-yl)octyl]acetamide | |
0.00012 | - |
HDAC1 | Homo sapiens | MS-275 | |
0.00012 | - |
HDAC3 | Homo sapiens | 2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo-1-(5-phenyl-1H-imidazol-2-yl)octyl]acetamide | |
0.00014 | - |
HDAC1 | Homo sapiens | (2S)-8-oxo-2-[(3-piperidin-1-ylpropanoyl)amino]-N-quinolin-3-ylnonanamide | |
0.00025 | - |
HDAC2 | Homo sapiens | MS-275 | |
0.00034 | - |
HDAC6 | Homo sapiens | 2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo-1-(5-phenyl-1H-imidazol-2-yl)octyl]acetamide | |
0.0004 | - |
HDAC3 | Homo sapiens | MS-275 | |
0.00067 | - |
HDAC1 | Homo sapiens | N-[(1S)-1-(6-chloro-1H-benzimidazol-2-yl)-7-oxooctyl]-2-(5-methoxy-2-methyl-1H-indol-3-yl)acetamide | |
0.00088 | - |
HDAC2 | Homo sapiens | N-[(1S)-1-(6-chloro-1H-benzimidazol-2-yl)-7-oxooctyl]-2-(5-methoxy-2-methyl-1H-indol-3-yl)acetamide | |
0.00097 | - |
HDAC6 | Homo sapiens | N-[(1S)-1-(6-chloro-1H-benzimidazol-2-yl)-7-oxooctyl]-2-(5-methoxy-2-methyl-1H-indol-3-yl)acetamide | |
0.001 | - |
HDAC3 | Homo sapiens | N-[(1S)-1-(6-chloro-1H-benzimidazol-2-yl)-7-oxooctyl]-2-(5-methoxy-2-methyl-1H-indol-3-yl)acetamide | |
0.0017 | - |
HDAC8 | Homo sapiens | vorinostat | |
0.005 | - |
HDAC8, larger than 0.005 | Homo sapiens | 2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo-1-(5-phenyl-1H-imidazol-2-yl)octyl]acetamide | |
0.01 | - |
HDAC5, larger than 0.010 | Homo sapiens | MS-275 | |
0.01 | - |
HDAC5, larger than 0.010 | Homo sapiens | 2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo-1-(5-phenyl-1H-imidazol-2-yl)octyl]acetamide | |
0.01 | - |
HDAC5, larger than 0.010 | Homo sapiens | N-[(1S)-1-(6-chloro-1H-benzimidazol-2-yl)-7-oxooctyl]-2-(5-methoxy-2-methyl-1H-indol-3-yl)acetamide | |
0.01 | - |
HDAC5, larger than 0.010 | Homo sapiens | 2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo-1-(5-phenyl-1H-imidazol-2-yl)nonyl]acetamide | |
0.01 | - |
HDAC6, larger than 0.010 | Homo sapiens | MS-275 | |
0.01 | - |
HDAC7, larger than 0.010 | Homo sapiens | MS-275 | |
0.01 | - |
HDAC7, larger than 0.010 | Homo sapiens | vorinostat | |
0.01 | - |
HDAC7, larger than 0.010 | Homo sapiens | 2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo-1-(5-phenyl-1H-imidazol-2-yl)octyl]acetamide | |
0.01 | - |
HDAC7, larger than 0.010 | Homo sapiens | N-[(1S)-1-(6-chloro-1H-benzimidazol-2-yl)-7-oxooctyl]-2-(5-methoxy-2-methyl-1H-indol-3-yl)acetamide | |
0.01 | - |
HDAC7, larger than 0.010 | Homo sapiens | 2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo-1-(5-phenyl-1H-imidazol-2-yl)nonyl]acetamide | |
0.01 | - |
HDAC8, larger than 0.010 | Homo sapiens | MS-275 | |
0.01 | - |
HDAC8, larger than 0.010 | Homo sapiens | N-[(1S)-1-(6-chloro-1H-benzimidazol-2-yl)-7-oxooctyl]-2-(5-methoxy-2-methyl-1H-indol-3-yl)acetamide |