Application | Comment | Organism |
---|---|---|
medicine | application of HDAC inhibitors in cancer cell lines and mouse model systems leads to interruption of the cell cycle, differentiation and apoptosis, clinical studies have shown tumor repression and improvement of patient symptoms without significant side effects | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-benzoylbenzoic acid | and hydroxamate analogs | Rattus norvegicus | |
3-benzoylpropanoic acid | and hydroxamate analogs | Rattus norvegicus | |
4-benzoylbutyric acid | and hydroxamate analogs | Rattus norvegicus | |
4-benzoylbutyric hydroxamic acid | - |
Rattus norvegicus | |
4-phenylbutyric acid | and hydroxamate analogs | Rattus norvegicus | |
5-phenylvaleric acid | and hydroxamate analogs | Rattus norvegicus | |
5-phenylvaleric hydroxamic acid | - |
Rattus norvegicus | |
Butyric acid | - |
Rattus norvegicus | |
sodium butyrate | - |
Rattus norvegicus | |
suberoylanilide hydroxamic acid | SAHA | Rattus norvegicus | |
trichostatin A | TSA | Rattus norvegicus | |
Valproic acid | - |
Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | - |
Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
AC-Arg-Gly-Lys(AC)-4-amino-7-methylcoumarin + H2O | substrate activity assay | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HDAC | - |
Rattus norvegicus |
histone deacetylase | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
activity assay | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.1 | - |
activity assay | Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.005 | - |
- |
Rattus norvegicus | 5-phenylvaleric hydroxamic acid | |
0.133 | - |
- |
Rattus norvegicus | 4-benzoylbutyric hydroxamic acid |