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Literature summary for 3.5.1.98 extracted from

  • Tischler, J.L.; Abuaita, B.; Cuthpert, S.C.; Fage, C.; Murphy, K.; Saxe, A.; Furr, E.B.; Hedrick, J.; Meyers, J.; Snare, D.; Zand, A.R.
    Simple inhibitors of histone deacetylase activity that combine features of short-chain fatty acid and hydroxamic acid inhibitors (2008), J. Enzyme Inhib. Med. Chem., 23, 549-555.
    View publication on PubMed

Application

Application Comment Organism
medicine application of HDAC inhibitors in cancer cell lines and mouse model systems leads to interruption of the cell cycle, differentiation and apoptosis, clinical studies have shown tumor repression and improvement of patient symptoms without significant side effects Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
3-benzoylbenzoic acid and hydroxamate analogs Rattus norvegicus
3-benzoylpropanoic acid and hydroxamate analogs Rattus norvegicus
4-benzoylbutyric acid and hydroxamate analogs Rattus norvegicus
4-benzoylbutyric hydroxamic acid
-
Rattus norvegicus
4-phenylbutyric acid and hydroxamate analogs Rattus norvegicus
5-phenylvaleric acid and hydroxamate analogs Rattus norvegicus
5-phenylvaleric hydroxamic acid
-
Rattus norvegicus
Butyric acid
-
Rattus norvegicus
sodium butyrate
-
Rattus norvegicus
suberoylanilide hydroxamic acid SAHA Rattus norvegicus
trichostatin A TSA Rattus norvegicus
Valproic acid
-
Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+
-
Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
AC-Arg-Gly-Lys(AC)-4-amino-7-methylcoumarin + H2O substrate activity assay Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
HDAC
-
Rattus norvegicus
histone deacetylase
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
activity assay Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.1
-
activity assay Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.005
-
-
Rattus norvegicus 5-phenylvaleric hydroxamic acid
0.133
-
-
Rattus norvegicus 4-benzoylbutyric hydroxamic acid