Literature summary for 3.5.1.98 extracted from

Perrino, E.; Cappelletti, G.; Tazzari, V.; Giavini, E.; Del Soldato, P.; Sparatore, A.
New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity (2008), Bioorg. Med. Chem. Lett., 18, 1893-1897.

Search for more literature for 3.5.1.98

Application

Application	Comment	Organism
medicine	HDAC inhibitors are a promising class of anticancer agents	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
2-[(methylsulfonyl)sulfanyl]ethanaminium bromide	-	Homo sapiens
2-[(methylsulfonyl)sulfanyl]ethyl 2-propylpentanoate	-	Homo sapiens
4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl 2-propylpentanoate	-	Homo sapiens
5-(4-hydroxyphenyl)-3H-1,2-dithiol-3-thione	-	Homo sapiens
Butyric acid	-	Homo sapiens
S-(2-hydroxyethyl) methanesulfonothioate	-	Homo sapiens
S-[2-[(2-propylpentanoyl)amino]ethyl]methanesulfonothioate	-	Homo sapiens
Valproic acid	-	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-549 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
HDAC	-	Homo sapiens
histone deacetylase	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00045	-	ADTOH	Homo sapiens	5-(4-hydroxyphenyl)-3H-1,2-dithiol-3-thione
0.0096	-	-	Homo sapiens	2-[(methylsulfonyl)sulfanyl]ethyl 2-propylpentanoate
0.0175	-	-	Homo sapiens	S-[2-[(2-propylpentanoyl)amino]ethyl]methanesulfonothioate
0.0564	-	-	Homo sapiens	4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl 2-propylpentanoate
0.102	-	-	Homo sapiens	S-(2-hydroxyethyl) methanesulfonothioate
0.198	-	-	Homo sapiens	2-[(methylsulfonyl)sulfanyl]ethanaminium bromide
0.995	-	-	Homo sapiens	Valproic acid

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Release 2023.1 (January 2023)