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Literature summary for 3.5.1.98 extracted from

  • Klampfer, L.; Huang, J.; Swaby, L.A.; Augenlicht, L.
    Requirement of histone deacetylase activity for signaling by STAT1 (2004), J. Biol. Chem., 279, 30358-30368.
    View publication on PubMed

Application

Application Comment Organism
medicine inhibitors of histone deacetylase activity sensitize colon cancer cells to interferon gamma-induced apoptosis through cooperative negative regulation of the Bcl-x expression Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information silencing of isoforms HDAC1, HDAC2, HDAC3 by RNAi markedly decreases interferon gamma-driven gene activation. Overexpression of the enzymes enhances STAT1-driven transcriptional activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Butyrate inhibition of histone deacetylase activity, resulting in prevention of interferon gamma-induced Janus kinase 1 activation, STAT1 phosphorylation, its nuclear translocation, and STAT1-dependent gene activation Homo sapiens
suberoylanilide hydroxamic acid inhibition of histone deacetylase activity, resulting in prevention of interferon gamma-induced Janus kinase 1 activation, STAT1 phosphorylation, its nuclear translocation, and STAT1-dependent gene activation Homo sapiens
trichostatin A inhibition of histone deacetylase activity, resulting in prevention of interferon gamma-induced Janus kinase 1 activation, STAT1 phosphorylation, its nuclear translocation, and STAT1-dependent gene activation Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
HCT-116 cell
-
Homo sapiens
-
HKE-3 cell
-
Homo sapiens
-
HT-29 cell
-
Homo sapiens
-