Literature summary for 3.5.1.98 extracted from

Huang, X.; Kadonaga, J.T.
Biochemical analysis of transcriptional repression by Drosophila histone deacetylase 1 (2001), J. Biol. Chem., 276, 12497-12500.

Search for more literature for 3.5.1.98

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Sf9 cells of full-length protein and of Gal4-dHDAC1, consisting of the N-terminal 147 amino acid residues of the yeast Gal4 protein fused to the N terminus of full-length dHDAC1 protein	Drosophila melanogaster

Inhibitors

Inhibitors	Comment	Organism	Structure
FR901228	Gal4-dHDAC1, consisting of the N-terminal 147 amino acid residues of the yeast Gal4 protein fused to the N terminus of full-length dHDAC1 protein, but not dHDAC1, is able to repress transcription in vitro. Transcriptional repression is blocked by the enzyme inhibitor FR901228	Drosophila melanogaster

Organism

Organism	UniProt	Comment	Textmining
Drosophila melanogaster	-	isoform dHDAC1, i.e. dRPD3	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	Gal4-dHDAC1, consisting of the N-terminal 147 amino acid residues of the yeast Gal4 protein fused to the N terminus of full-length dHDAC1 protein, but not dHDAC1, is able to repress transcription in vitro. Transcriptional repression is blocked by the enzyme inhibitor FR901228	Drosophila melanogaster	?	-	?

Synonyms

Synonyms	Comment	Organism
dRPD3	-	Drosophila melanogaster

Cofactor

Cofactor	Comment	Organism	Structure
additional information	deacetylation by isoform dHDAC1 does not require any additional cofactors	Drosophila melanogaster

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Release 2023.1 (January 2023)