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Literature summary for 3.5.1.98 extracted from

  • Hartman, H.B.; Yu, J.; Alenghat, T.; Ishizuka, T.; Lazar, M.A.
    The histone-binding code of nuclear receptor co-repressors matches the substrate specificity of histone deacetylase 3 (2005), EMBO Rep., 6, 445-451.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
isoform HDAC3, expression in NIH 3T3 fibroblasts Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-acetyl-lysine-histone H4 + H2O Mus musculus
-
acetate + histone H4 rate of deacetylation is not uniform. H4 K5 is deacetylated first, followed by K8, K12 and K16. The specificity of deacetylation and the histone-binding preference of transcriptional co-repressors N-CoR/SMRT match each other ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
isoform HDAC3
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-lysine-histone H3 + H2O
-
Mus musculus acetate + histone H3 individual lysine residues in the H3 tail are deacetylated at similar rates ?
N-acetyl-lysine-histone H4 + H2O
-
Mus musculus acetate + histone H4 rate of deacetylation is not uniform. H4 K5 is deacetylated first, followed by K8, K12 and K16. The specificity of deacetylation and the histone-binding preference of transcriptional co-repressors N-CoR/SMRT match each other ?
N-acetyl-lysine-histone H4 + H2O
-
Mus musculus acetate + histone H4 rate of deacetylation by isoform HDAC3 is not uniform. H4 K5 is deacetylated first, followed by K8, K12 and K16. The specificity of deacetylation and the histone-binding preference of transcriptional co-repressors N-CoR/SMRT match each other ?