Literature summary for 3.5.1.98 extracted from

Brogdon, J.L.; Xu, Y.; Szabo, S.J.; An, S.; Buxton, F.; Cohen, D.; Huang, Q.
Histone deacetylase activities are required for innate immune cell control of Th1 but not Th2 effector cell function (2007), Blood, 109, 1123-1130.

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Application

Application	Comment	Organism
medicine	general inhibition of histone deacetylases alters the balance of T helper 1 and T helper 2 effector cell activation and migration	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
LAQ824	enzyme inhibition results in altered Toll-like receptor 4-dependent activation and function of macrophages and dendritic cells. Pan-HDAC inhibition modulates only a limited set of genes involved in distinct arms of immune responses, specifically dendritic cell-controlled T helper 1 effector, but not T helper 2 effector cell activation and migration. It also inhibits dendritic cell-mediated monocyte, but not neutrophil chemotaxis	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
dendritic cell	-	Homo sapiens	-
macrophage	-	Homo sapiens	-

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Release 2023.1 (January 2023)