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Literature summary for 3.5.1.98 extracted from

  • Buggy, J.J.; Sideris, M.L.; Mak, P.; Lorimer, D.D.; McIntosh, B.; Clark, J.M.
    Cloning and characterization of a novel human histone deacetylase, HDAC8 (2000), Biochem. J., 350, 199-205.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.1.98

Cloned(Commentary)

Cloned (Comment) Organism
expression in HeLa and Sf9 cells, FLAG-tagged protein Homo sapiens

Protein Variants

Protein Variants Comment Organism
H142A/H143A less than 20% residual activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Butyrate
-
 Homo sapiens
trichostatin A
-
 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
42000
-
 x * 42000, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BY41 isoform HDAC8
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N6-lysine acetylated histone H3 + H2O
-
 Homo sapiens histone H3 + acetate
-
 ?
N6-lysine acetylated histone H4 + H2O
-
 Homo sapiens histone H4 + acetate
-
 ?
N6-lysine acetylated histone H4 peptide + H2O peptide of N-terminal 20 amino acids Homo sapiens histone H4 peptide + acetate
-
 ?

Subunits

Subunits Comment Organism
? x * 42000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
HDAC8
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000003
-
 pH 8.0 Homo sapiens trichostatin A
0.35
-
 pH 8.0 Homo sapiens Butyrate