BRENDA - Enzyme Database show
show all sequences of 3.5.1.98

Factors affecting the substrate specificity of histone deacetylases

Riester, D.; Hildmann, C.; Gruenewald, S.; Beckers, T.; Schwienhorst, A.; Biochem. Biophys. Res. Commun. 357, 439-445 (2007)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
isoform HDAC8, expression in Escherichia coli. Isoforms HDAC1, HDAC6, expression in HEK-293 cell, HDAC3, expression in insect system, FLAg-tagged proteins
Homo sapiens
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.00069
-
Ac-IHK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC1
Homo sapiens
0.00228
-
Ac-FEK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC6
Homo sapiens
0.00244
-
Ac-DQK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC3
Homo sapiens
0.00303
-
Ac-LIK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC1
Homo sapiens
0.00405
-
Ac-GSK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC3
Homo sapiens
0.0043
-
Ac-GGK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC6
Homo sapiens
0.0044
-
Ac-KYK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC8
Homo sapiens
0.0046
-
Ac-FEK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC3
Homo sapiens
0.005
-
Ac-KWK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC1
Homo sapiens
0.0054
-
Ac-KGK(acetyl)-7-amido-4-methylcoumarin
isoform FB188 HDAH
Homo sapiens
0.0056
-
Ac-KYK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC1
Homo sapiens
0.00625
-
Ac-IHK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC6
Homo sapiens
0.0069
-
Ac-LYK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC3
Homo sapiens
0.00745
-
Ac-KYK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC3
Homo sapiens
0.0091
-
Ac-IHK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC8
Homo sapiens
0.01
-
Ac-GGK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC3
Homo sapiens
0.01
-
Ac-PFK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC8
Homo sapiens
0.0108
-
Ac-GSK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC8
Homo sapiens
0.011
-
Ac-GSK(acetyl)-7-amido-4-methylcoumarin
isoform FB188 HDAH
Homo sapiens
0.0117
-
Ac-FEK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC1
Homo sapiens
0.0119
-
Ac-VLK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC3
Homo sapiens
0.0123
-
Ac-GS(PO3)K(acetyl)-7-amido-4-methylcoumarin
isoform HDAC6
Homo sapiens
0.0124
-
Ac-ILK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC3
Homo sapiens
0.0133
-
Ac-GSK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC1
Homo sapiens
0.0138
-
Ac-GGK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC1
Homo sapiens
0.0148
-
Ac-IHK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC3
Homo sapiens
0.015
-
Ac-VLK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC1
Homo sapiens
0.01646
-
Ac-DQK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC6
Homo sapiens
0.019
-
Ac-KSK(acetyl)-7-amido-4-methylcoumarin
isoform FB188 HDAH
Homo sapiens
0.0221
-
Ac-VLK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC6
Homo sapiens
0.0241
-
Ac-GSK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC6
Homo sapiens
0.0276
-
Ac-GS(PO3)K(acetyl)-7-amido-4-methylcoumarin
isoform HDAC3
Homo sapiens
0.0294
-
Ac-LYK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC1
Homo sapiens
0.03
-
Ac-LYK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC6
Homo sapiens
0.0353
-
Ac-FEK(acetyl)-7-amido-4-methylcoumarin
isoform FB188 HDAH
Homo sapiens
0.0359
-
Ac-FEK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC8
Homo sapiens
0.0391
-
Ac-GGK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC8
Homo sapiens
0.046
-
Ac-GS(PO3)K(acetyl)-7-amido-4-methylcoumarin
isoform HDAC1
Homo sapiens
0.0489
-
Ac-GS(PO3)K(acetyl)-7-amido-4-methylcoumarin
isoform HDAC8
Homo sapiens
0.0666
-
Ac-GS(PO3)K(acetyl)-7-amido-4-methylcoumarin
isoform FB188 HDAH
Homo sapiens
0.0877
-
Ac-GGK(acetyl)-7-amido-4-methylcoumarin
isoform FB188 HDAH
Homo sapiens
0.107
-
Ac-KYK(acetyl)-7-amido-4-methylcoumarin
isoform FB188 HDAH
Homo sapiens
0.108
-
Ac-IHK(acetyl)-7-amido-4-methylcoumarin
isoform FB188 HDAH
Homo sapiens
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Ac-DQK(acetyl)-7-amido-4-methylcoumarin + H2O
-
677964
Homo sapiens
?
-
-
-
?
Ac-FEK(acetyl)-7-amido-4-methylcoumarin + H2O
-
677964
Homo sapiens
?
-
-
-
?
Ac-GGK(acetyl)-7-amido-4-methylcoumarin + H2O
-
677964
Homo sapiens
?
-
-
-
?
Ac-GS(PO3)K(acetyl)-7-amido-4-methylcoumarin + H2O
-
677964
Homo sapiens
?
-
-
-
?
Ac-GSK(acetyl)-7-amido-4-methylcoumarin + H2O
-
677964
Homo sapiens
?
-
-
-
?
Ac-IHK(acetyl)-7-amido-4-methylcoumarin + H2O
-
677964
Homo sapiens
?
-
-
-
?
Ac-ILK(acetyl)-7-amido-4-methylcoumarin + H2O
-
677964
Homo sapiens
?
-
-
-
?
Ac-KGK(acetyl)-7-amido-4-methylcoumarin + H2O
-
677964
Homo sapiens
?
-
-
-
?
Ac-KSK(acetyl)-7-amido-4-methylcoumarin + H2O
-
677964
Homo sapiens
?
-
-
-
?
Ac-KWK(acetyl)-7-amido-4-methylcoumarin + H2O
-
677964
Homo sapiens
?
-
-
-
?
Ac-KYK(acetyl)-7-amido-4-methylcoumarin + H2O
-
677964
Homo sapiens
?
-
-
-
?
Ac-LIK(acetyl)-7-amido-4-methylcoumarin + H2O
-
677964
Homo sapiens
?
-
-
-
?
Ac-LYK(acetyl)-7-amido-4-methylcoumarin + H2O
-
677964
Homo sapiens
?
-
-
-
?
Ac-PFK(acetyl)-7-amido-4-methylcoumarin + H2O
-
677964
Homo sapiens
?
-
-
-
?
Ac-VLK(acetyl)-7-amido-4-methylcoumarin + H2O
-
677964
Homo sapiens
?
-
-
-
?
Cloned(Commentary) (protein specific)
Commentary
Organism
isoform HDAC8, expression in Escherichia coli. Isoforms HDAC1, HDAC6, expression in HEK-293 cell, HDAC3, expression in insect system, FLAg-tagged proteins
Homo sapiens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.00069
-
Ac-IHK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC1
Homo sapiens
0.00228
-
Ac-FEK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC6
Homo sapiens
0.00244
-
Ac-DQK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC3
Homo sapiens
0.00303
-
Ac-LIK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC1
Homo sapiens
0.00405
-
Ac-GSK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC3
Homo sapiens
0.0043
-
Ac-GGK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC6
Homo sapiens
0.0044
-
Ac-KYK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC8
Homo sapiens
0.0046
-
Ac-FEK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC3
Homo sapiens
0.005
-
Ac-KWK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC1
Homo sapiens
0.0054
-
Ac-KGK(acetyl)-7-amido-4-methylcoumarin
isoform FB188 HDAH
Homo sapiens
0.0056
-
Ac-KYK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC1
Homo sapiens
0.00625
-
Ac-IHK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC6
Homo sapiens
0.0069
-
Ac-LYK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC3
Homo sapiens
0.00745
-
Ac-KYK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC3
Homo sapiens
0.0091
-
Ac-IHK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC8
Homo sapiens
0.01
-
Ac-GGK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC3
Homo sapiens
0.01
-
Ac-PFK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC8
Homo sapiens
0.0108
-
Ac-GSK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC8
Homo sapiens
0.011
-
Ac-GSK(acetyl)-7-amido-4-methylcoumarin
isoform FB188 HDAH
Homo sapiens
0.0117
-
Ac-FEK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC1
Homo sapiens
0.0119
-
Ac-VLK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC3
Homo sapiens
0.0123
-
Ac-GS(PO3)K(acetyl)-7-amido-4-methylcoumarin
isoform HDAC6
Homo sapiens
0.0124
-
Ac-ILK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC3
Homo sapiens
0.0133
-
Ac-GSK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC1
Homo sapiens
0.0138
-
Ac-GGK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC1
Homo sapiens
0.0148
-
Ac-IHK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC3
Homo sapiens
0.015
-
Ac-VLK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC1
Homo sapiens
0.01646
-
Ac-DQK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC6
Homo sapiens
0.019
-
Ac-KSK(acetyl)-7-amido-4-methylcoumarin
isoform FB188 HDAH
Homo sapiens
0.0221
-
Ac-VLK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC6
Homo sapiens
0.0241
-
Ac-GSK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC6
Homo sapiens
0.0276
-
Ac-GS(PO3)K(acetyl)-7-amido-4-methylcoumarin
isoform HDAC3
Homo sapiens
0.0294
-
Ac-LYK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC1
Homo sapiens
0.03
-
Ac-LYK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC6
Homo sapiens
0.0353
-
Ac-FEK(acetyl)-7-amido-4-methylcoumarin
isoform FB188 HDAH
Homo sapiens
0.0359
-
Ac-FEK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC8
Homo sapiens
0.0391
-
Ac-GGK(acetyl)-7-amido-4-methylcoumarin
isoform HDAC8
Homo sapiens
0.046
-
Ac-GS(PO3)K(acetyl)-7-amido-4-methylcoumarin
isoform HDAC1
Homo sapiens
0.0489
-
Ac-GS(PO3)K(acetyl)-7-amido-4-methylcoumarin
isoform HDAC8
Homo sapiens
0.0666
-
Ac-GS(PO3)K(acetyl)-7-amido-4-methylcoumarin
isoform FB188 HDAH
Homo sapiens
0.0877
-
Ac-GGK(acetyl)-7-amido-4-methylcoumarin
isoform FB188 HDAH
Homo sapiens
0.107
-
Ac-KYK(acetyl)-7-amido-4-methylcoumarin
isoform FB188 HDAH
Homo sapiens
0.108
-
Ac-IHK(acetyl)-7-amido-4-methylcoumarin
isoform FB188 HDAH
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Ac-DQK(acetyl)-7-amido-4-methylcoumarin + H2O
-
677964
Homo sapiens
?
-
-
-
?
Ac-FEK(acetyl)-7-amido-4-methylcoumarin + H2O
-
677964
Homo sapiens
?
-
-
-
?
Ac-GGK(acetyl)-7-amido-4-methylcoumarin + H2O
-
677964
Homo sapiens
?
-
-
-
?
Ac-GS(PO3)K(acetyl)-7-amido-4-methylcoumarin + H2O
-
677964
Homo sapiens
?
-
-
-
?
Ac-GSK(acetyl)-7-amido-4-methylcoumarin + H2O
-
677964
Homo sapiens
?
-
-
-
?
Ac-IHK(acetyl)-7-amido-4-methylcoumarin + H2O
-
677964
Homo sapiens
?
-
-
-
?
Ac-ILK(acetyl)-7-amido-4-methylcoumarin + H2O
-
677964
Homo sapiens
?
-
-
-
?
Ac-KGK(acetyl)-7-amido-4-methylcoumarin + H2O
-
677964
Homo sapiens
?
-
-
-
?
Ac-KSK(acetyl)-7-amido-4-methylcoumarin + H2O
-
677964
Homo sapiens
?
-
-
-
?
Ac-KWK(acetyl)-7-amido-4-methylcoumarin + H2O
-
677964
Homo sapiens
?
-
-
-
?
Ac-KYK(acetyl)-7-amido-4-methylcoumarin + H2O
-
677964
Homo sapiens
?
-
-
-
?
Ac-LIK(acetyl)-7-amido-4-methylcoumarin + H2O
-
677964
Homo sapiens
?
-
-
-
?
Ac-LYK(acetyl)-7-amido-4-methylcoumarin + H2O
-
677964
Homo sapiens
?
-
-
-
?
Ac-PFK(acetyl)-7-amido-4-methylcoumarin + H2O
-
677964
Homo sapiens
?
-
-
-
?
Ac-VLK(acetyl)-7-amido-4-methylcoumarin + H2O
-
677964
Homo sapiens
?
-
-
-
?
Other publictions for EC 3.5.1.98
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
735224
Kim
Kinetics and thermodynamics of ...
Homo sapiens
Protein Sci.
24
354-365
2015
-
-
1
-
-
-
2
-
-
2
-
-
-
1
-
-
1
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
733081
Meyners
Kinetic method for the large-s ...
Alcaligenes sp., Alcaligenes sp. DSM 11172, Homo sapiens
Anal. Biochem.
460
39-46
2014
-
-
2
-
-
-
22
2
-
-
-
-
-
7
-
-
-
-
-
1
-
-
2
-
2
-
-
-
2
-
-
-
2
-
-
-
-
2
-
-
-
-
-
44
4
4
-
-
-
-
-
-
-
-
-
2
-
-
2
-
4
-
-
-
4
-
-
-
-
-
-
-
-
-
733817
Karthikeyan
Functional characterization of ...
Candida albicans, Candida albicans ATCC 90028
F1000Res.
2
238
2013
-
-
1
-
-
-
4
-
-
1
-
2
-
5
-
-
1
-
-
1
-
-
6
-
1
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
2
4
-
-
-
1
-
2
-
-
-
1
-
1
-
-
6
-
1
-
-
-
1
-
-
-
-
3
3
-
-
-
733951
Huang
Characterization of the regula ...
Mus musculus
Hepatology
57
1742-1751
2013
-
-
-
-
-
-
1
-
2
1
-
-
-
3
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
1
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
2
2
1
-
-
735001
Ma
Histone deacetylase 2 (HDAC2) ...
Mus musculus
PLoS Genet.
9
e1003377
2013
-
-
-
-
1
-
-
-
2
-
-
1
-
3
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
718758
Janzer
Lysine-specific demethylase 1 ...
Homo sapiens
Biochem. Biophys. Res. Commun.
421
665-670
2012
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
719092
Guan
Design, synthesis and prelimin ...
Homo sapiens
Bioorg. Med. Chem.
20
3865-3872
2012
-
-
-
-
-
-
7
-
-
-
-
-
-
1
-
-
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3
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-
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-
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-
6
-
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-
-
-
-
-
6
7
-
-
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-
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-
-
3
-
-
-
-
-
-
-
-
-
-
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-
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719095
Henkes
Synthesis and biochemical anal ...
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Bioorg. Med. Chem.
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1
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4
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1
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-
2
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-
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15
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1
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1
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4
15
4
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-
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-
1
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2
-
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-
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719304
Terracciano
Design, synthesis, and biologi ...
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ChemMedChem
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2012
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1
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1
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2
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1
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2
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-
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4
-
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1
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4
5
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1
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-
1
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-
2
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-
-
-
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Icardi
Opposed regulation of type I I ...
Homo sapiens
FASEB J.
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-
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1
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1
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-
-
-
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1
1
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720163
Chen
Histone deacetylase activity i ...
Homo sapiens
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2012
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2
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1
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2
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-
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734443
Wong
Pharmacokinetic optimization o ...
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735000
Hnisz
A histone deacetylase adjusts ...
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3
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1
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3
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-
3
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-
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-
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2
2
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Munkhjargal
Cloning and characterization o ...
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1
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1
1
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1
1
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1
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1
2
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1
1
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719058
Shultz
The design, synthesis and stru ...
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5
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1
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5
5
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1
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719061
Singh
Histone deacetylase activators ...
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Bioorg. Med. Chem. Lett.
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1
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3
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2
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1
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2
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719131
Feng
Expression, purification, and ...
Homo sapiens
Biosci. Trends
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2011
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1
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2
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1
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1
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719174
Carneiro
Histone deacetylase activity i ...
Xenopus laevis
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1
1
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719258
Mihaylova
Class IIa histone deacetylases ...
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2011
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1
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-
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1
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Muralidhar
Histone deacetylase 9 activate ...
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2
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2
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1
1
1
1
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720815
Hnilicova
Histone deacetylase activity m ...
Homo sapiens
PLoS ONE
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2011
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1
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1
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-
-
-
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1
1
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711044
Kawabata
Increased activity and express ...
Homo sapiens
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1
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1
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1
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1
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-
-
-
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-
-
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1
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1
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Zhuang
Requirement of a novel splicin ...
Homo sapiens
Biochem. Biophys. Res. Commun.
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608-613
2010
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1
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-
1
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-
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-
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-
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1
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2
1
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1
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1
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1
1
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711416
Chetan
Design, synthesis and anticanc ...
Homo sapiens
Bioorg. Med. Chem. Lett.
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2010
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3
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3
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3
10
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3
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711451
Zhang
Design, synthesis and prelimin ...
Homo sapiens
Bioorg. Med. Chem.
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2010
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40
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40
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1
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711660
Davies
Troglitazone inhibits histone ...
Homo sapiens
Cancer Lett.
288
236-250
2010
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1
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711764
Hui
Temporal and spatial regulatio ...
Homo sapiens
Circ. Res.
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1180-1183
2010
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1
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1
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-
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1
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1
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711850
Fiesel
Knockdown of transactive respo ...
Homo sapiens
EMBO J.
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2010
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2
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1
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1
1
1
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711880
Halbert
A Plasmodium falciparum transc ...
Plasmodium falciparum
Eukaryot. Cell
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2010
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1
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1
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2
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1
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1
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712181
Hayashi
Type-specific roles of histone ...
Homo sapiens
Int. J. Cancer
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2010
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Doyle
Redox signaling, alkylation (c ...
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J. Biol. Chem.
285
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2010
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4
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3
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4
4
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1
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1
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Gantt
Activation and inhibition of h ...
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285
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1
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2
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2
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2
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1
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1
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2
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713009
Lee
Inhibition of histone deacetyl ...
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Mol. Cell. Biochem.
343
163-171
2010
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1
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2
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-
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-
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1
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-
-
-
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2
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-
-
-
-
-
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1
2
2
1
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713036
Lee
Inhibition of histone deacetyl ...
Homo sapiens
Mol. Cells
30
107-112
2010
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3
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4
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2
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1
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3
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2
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-
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2
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713087
Hutt
Reduced histone deacetylase 7 ...
Homo sapiens
Nat. Chem. Biol.
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2010
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713115
Jawerka
The specific role of histone d ...
Mus musculus
Neuron Glia Biol.
6
93-107
2010
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-
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-
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-
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2
2
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713157
Leone
CCDC6 represses CREB1 activity ...
Homo sapiens
Oncogene
29
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2010
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1
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1
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1
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-
-
-
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FOXP3 up-regulates p21 express ...
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Alpha-keto acid metabolites of ...
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A novel domain in histone deac ...
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1
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6
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Activation of histone deacetyl ...
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Farooq
Histone deacetylase 3 (hdac3) ...
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1
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Knutson
Liver-specific deletion of his ...
Mus musculus
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1
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Schuetz
Human HDAC7 harbors a class II ...
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J. Biol. Chem.
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2
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4
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14
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1
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1
3
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14
7
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3
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1
-
1
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1
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2
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Tischler
Simple inhibitors of histone d ...
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1
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1
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1
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2
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1
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2
12
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1
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1
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1
-
1
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699429
Jones
A novel series of potent and s ...
Homo sapiens
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28
16
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6
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1
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699443
Weerasinghe
Residues in the 11 A channel o ...
Homo sapiens
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2008
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1
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3
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1
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1
1
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-
10
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3
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2
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1
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1
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3
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1
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699927
Wang
Enhanced histone deacetylase e ...
Homo sapiens
Leuk. Lymphoma
49
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2008
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1
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1
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4
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1
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700134
Duong
Specific activity of class II ...
Homo sapiens
Mol. Cancer Res.
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2008
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1
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5
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20
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10
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5
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700495
Ray
Requirement of histone deacety ...
Homo sapiens
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36
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2008
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1
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1
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3
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700974
Ishii
Histone deacetylase 3 localize ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
105
4179-4184
2008
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2
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1
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1
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2
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2
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677964
Riester
Factors affecting the substrat ...
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357
439-445
2007
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677978
Song
Cloning, expression, and bioch ...
Thermus caldophilus, Thermus caldophilus GK24
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361
55-61
2007
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1
1
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1
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1
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2
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1
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3
1
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1
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1
1
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1
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678443
Glenisson
Histone deacetylase 4 is requi ...
Homo sapiens
Biochim. Biophys. Acta
1773
1572-1582
2007
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1
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1
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2
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1
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678911
Brogdon
Histone deacetylase activities ...
Homo sapiens
Blood
109
1123-1130
2007
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1
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2
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679031
Harms
Histone deacetylase 2 modulate ...
Mus musculus
Cancer Res.
67
3145-3152
2007
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1
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1
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1
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1
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679594
Shwab
Histone deacetylase activity r ...
Aspergillus nidulans
Eukaryot. Cell
6
1656-1664
2007
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1
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1
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1
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1
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681304
Liu
Design and synthesis of a pote ...
Homo sapiens
J. Med. Chem.
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2003-2006
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13
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5
1
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1
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681509
Broide
Distribution of histone deacet ...
Rattus norvegicus
J. Mol. Neurosci.
31
47-58
2007
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1
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682566
Guo
Crystal structure of a conserv ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
104
4297-4302
2007
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1
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677911
Zou
Characterization of the two ca ...
Homo sapiens
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341
45-50
2006
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1
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1
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678192
Gantt
Catalytic activity and inhibit ...
Homo sapiens
Biochemistry
45
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2006
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1
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3
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3
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1
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1
3
3
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5
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1
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2
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3
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679066
Myzak
Sulforaphane inhibits histone ...
Homo sapiens
Carcinogenesis
27
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2006
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1
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3
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-
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679110
Fong
Arabidopsis thaliana histone d ...
Arabidopsis thaliana
Cell Res.
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479-488
2006
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1
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679508
Hartman
The histone-binding code of nu ...
Mus musculus
EMBO Rep.
6
445-451
2005
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1
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1
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3
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681145
Rossig
Histone deacetylase activity i ...
Mus musculus
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1825-1835
2005
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1
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1
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681276
Suzuki
Novel Inhibitors of human hist ...
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48
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2005
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1
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15
1
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1
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1
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680626
Klampfer
Requirement of histone deacety ...
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279
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3
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681374
Han
Mechanism of recruitment of cl ...
Homo sapiens
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2004
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682501
Vannini
Crystal structure of a eukaryo ...
Homo sapiens
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2004
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Characterization of inhibitor- ...
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680619
Kao
Isolation and characterization ...
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Cloning and functional charact ...
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Molecular cloning and characte ...
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Human class I histone deacetyl ...
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1
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682156
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Identification of HDAC10, a no ...
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679486
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A role for histone deacetylase ...
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680614
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Biochemical analysis of transc ...
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680615
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Human HDAC7 histone deacetylas ...
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Histone deacetylase is a direc ...
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Pflum
Histone deacetylase 1 phosphor ...
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682596
Zhou
Cloning and characterization o ...
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Cloning and characterization o ...
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678125
Lechner
RPD3-Type Histone deacetylases ...
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Sun
Purification and characterizat ...
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Fischle
A new family of human histone ...
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Finnin
Structures of a histone deacet ...
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Hassig
A role for histone deacetylase ...
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