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Literature summary for 3.5.1.92 extracted from

  • Giessner, C.; Millet, V.; Mostert, K.J.; Gensollen, T.; Vu Manh, T.P.; Garibal, M.; Dieme, B.; Attaf-Bouabdallah, N.; Chasson, L.; Brouilly, N.; Laprie, C.; Lesluyes, T.; Blay, J.Y.; Shintu, L.; Martin, J.C.; Strauss, E.; Galland, F.; Naquet, P.
    Vnn1 pantetheinase limits the Warburg effect and sarcoma growth by rescuing mitochondrial activity (2018), Life Sci. Alliance, 1, e201800073 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.1.92

Application

Application Comment Organism
diagnostics enzyme Vnn1 is a valid biomarker for aggressive soft tissue sarcomas (STS) prognosis Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information construction of in p16/p19-/- mutant mice. Comparison of mouse survival and tumor incidence in three independent cohorts of p16/p19/Vnn1-/- versus p16/p19-/- mice, derived from two independently derived crosses between p16/p19-/- and Vnn1-/- mice. Whereas 35% p16p19-/- mice progressively develop lethal tumors within 220 days, 70% p16p19/Vnn1-/- die of aggressive tumors before 220 days. Whereas p16p19-/- mice develop various tumor types with a majority of lymphomas, p16/p19/Vnn1-/- mice predominantly develop skin STS typed as fibrosarcomas Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
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 Mus musculus 5739
-

Organism

Organism UniProt Comment Textmining
Mus musculus Q9Z0K8
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibrosarcoma cell
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
pantetheinase
-
 Mus musculus
VNN1
-
 Mus musculus
Vnn1 pantetheinase
-
 Mus musculus

General Information

General Information Comment Organism
malfunction Vnn1 deficiency favors soft tissue sarcoma development in p16/p19-/- mice Mus musculus
metabolism enzyme Vnn1 is a valid biomarker for aggressive soft tissue sarcomas (STS) prognosis. Analysis of a route to regulate tumor growth rates through the modulation of CoA and cysteamine levels Mus musculus
physiological function Vnn1 pantetheinase acts as a tumor suppressor for the development of aggressive soft tissue sarcomas (STS). The two products of pantetheinase activity exert complementary effects on the tumor, explaining the basis for Vnn1's suppression on tumor growth. Pantothenate production restores CoA levels leading to an enhanced mitochondrial activity, whereas cysteamine reduces glycolysis and prevents the transition to the Warburg effect, a feature of the most aggressive tumors. Vnn1 expression antagonizes the glycolytic switch in Ras-driven tumors. Vnn1 expression antagonizes the glycolytic switch in Ras-driven tumors Mus musculus