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Literature summary for 3.5.1.92 extracted from

  • Bartucci, R.; Salvati, A.; Olinga, P.; Boersma, Y.L.
    Vanin 1 its physiological function and role in diseases (2019), Int. J. Mol. Sci., 20, E3891 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.1.92

Protein Variants

Protein Variants Comment Organism
additional information development of vnn1 KO mice, which do not have an obvious spontaneous phenotype, they are resistant to inflammation and oxidative stress, thus indisputably proving a correlation between vanin 1, its pantetheinase activity and pro-inflammatory mediators Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
RR6 shows high specificity towards vanin 1 and competitively and reversibly inhibits pantetheinase activity at nanomolar concentration Mus musculus
RR6 shows high specificity towards vanin 1 and competitively and reversibly inhibits pantetheinase activity at nanomolar concentration Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane bound Rattus norvegicus 16020
-
membrane bound Mus musculus 16020
-
membrane bound Sus scrofa 16020
-
additional information vanin 1 is membrane-associated via a glycosylphosphatidylinositol (GPI)-anchor, though soluble enzyme forms are detected as well Mus musculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(R)-pantetheine + H2O Rattus norvegicus
-
 (R)-pantothenate + 2-aminoethanethiol
-
 ?
(R)-pantetheine + H2O Mus musculus
-
 (R)-pantothenate + 2-aminoethanethiol
-
 ?
(R)-pantetheine + H2O Sus scrofa
-
 (R)-pantothenate + 2-aminoethanethiol
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9Z0K8
-
-
Rattus norvegicus
-
-
-
Sus scrofa Q9BDJ5
-
-

Source Tissue

Source Tissue Comment Organism Textmining
gut epithelium
-
 Mus musculus
-
hepatocyte vanin 1 expression specifically by the centrilobular hepatocytes in zone 3 adjacent to the central vein Mus musculus
-
intestine
-
 Rattus norvegicus
-
intestine
-
 Mus musculus
-
intestine
-
 Sus scrofa
-
kidney
-
 Rattus norvegicus
-
kidney
-
 Mus musculus
-
kidney
-
 Sus scrofa
-
liver
-
 Rattus norvegicus
-
liver
-
 Mus musculus
-
liver
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-pantetheine + H2O
-
 Rattus norvegicus (R)-pantothenate + 2-aminoethanethiol
-
 ?
(R)-pantetheine + H2O
-
 Mus musculus (R)-pantothenate + 2-aminoethanethiol
-
 ?
(R)-pantetheine + H2O
-
 Sus scrofa (R)-pantothenate + 2-aminoethanethiol
-
 ?

Synonyms

Synonyms Comment Organism
vanin 1
-
 Rattus norvegicus
vanin 1
-
 Mus musculus
vanin 1
-
 Sus scrofa
vascular non-inflammatory molecule-1
-
 Rattus norvegicus
vascular non-inflammatory molecule-1
-
 Mus musculus
vascular non-inflammatory molecule-1
-
 Sus scrofa
VNN1
-
 Mus musculus
VNN1
-
 Sus scrofa

Expression

Organism Comment Expression
Mus musculus PPAR-alpha KO mice show a negligible liver vnn1 expression, even after stimulation with various agonists down
Mus musculus upon administration of the PPAR-alpha agonists fenofibrate, clofibrate, or Wy-14,643, gene vnn1 expression is increased. The transcription of vnn1 itself is activated by PPAR-alpha coactivator 1 (PGC-1) in complex with the hepatocyte nuclear factor-4alpha (HNF-4alpha). In turn, this complex is mediated by the Akt signaling pathway up

General Information

General Information Comment Organism
malfunction PPAR-alpha KO mice show a negligible liver vnn1 expression, even after stimulation with various agonists. Vanin 1 overexpression increases glucose output by specifically increasing the hepatic transcription levels of gluconeogenic genes, while vnn1 knockdown decreases the glucose output of murine hepatocytes Mus musculus
metabolism formation of pantothenic acid allows for a continuous production of CoA, as pantothenic acid is a structural component of this cofactor. In addition, pantothenic acid appears to have profibrotic effects, being involved in the promotion of proliferation and migration of dermal fibroblasts. Moreover, pantothenic acid contributes to restoring CoA levels in the mitochondria, resulting in enhanced mitochondrial activity. Vanin 1 also plays a role in the regulation of a number of metabolic pathways Rattus norvegicus
metabolism formation of pantothenic acid allows for a continuous production of CoA, as pantothenic acid is a structural component of this cofactor. In addition, pantothenic acid appears to have profibrotic effects, being involved in the promotion of proliferation and migration of dermal fibroblasts. Moreover, pantothenic acid contributes to restoring CoA levels in the mitochondria, resulting in enhanced mitochondrial activity. Vanin 1 also plays a role in the regulation of a number of metabolic pathways Sus scrofa
metabolism formation of pantothenic acid allows for a continuous production of CoA, as pantothenic acid is a structural component of this cofactor. In addition, pantothenic acid appears to have profibrotic effects, being involved in the promotion of proliferation and migration of dermal fibroblasts. Moreover, pantothenic acid contributes to restoring CoA levels in the mitochondria, resulting in enhanced mitochondrial activity. Vanin 1 also plays a role in the regulation of a number of metabolic pathways. In fact, the vnn1 gene is one of the positive targets of the peroxisome proliferator-activated receptor alpha (PPAR-alpha) in mouse liver. PPAR-alpha is a key regulator of the liver's response to fasting Mus musculus
physiological function vanin 1 breaks down pantetheine in cysteamine and pantothenic acid, a precursor of coenzyme A. Its physiological role is not strictly related to coenzyme A metabolism, lipid metabolism, and energy production. It also plays a role under physiological conditions in relation to oxidative stress and inflammation. Vanin's enzymatic activity is of key importance in certain diseases, either for its protective effect or as a sensitizer, depending on the diseased organ. But vanin-1's primary function is the recycling of pantothenic acid (vitamin B5), an important precursor in the biosynthesis of coenzymeA (CoA). Vanin 1 also plays a role in the regulation of a number of metabolic pathways Rattus norvegicus
physiological function vanin 1 breaks down pantetheine in cysteamine and pantothenic acid, a precursor of coenzyme A. Its physiological role is not strictly related to coenzyme A metabolism, lipid metabolism, and energy production. It also plays a role under physiological conditions in relation to oxidative stress and inflammation. Vanin's enzymatic activity is of key importance in certain diseases, either for its protective effect or as a sensitizer, depending on the diseased organ. But vanin-1's primary function is the recycling of pantothenic acid (vitamin B5), an important precursor in the biosynthesis of coenzymeA (CoA). Vanin 1 also plays a role in the regulation of a number of metabolic pathways Sus scrofa
physiological function vanin 1 breaks down pantetheine in cysteamine and pantothenic acid, a precursor of coenzyme A. Its physiological role is not strictly related to coenzyme A metabolism, lipid metabolism, and energy production. It also plays a role under physiological conditions in relation to oxidative stress and inflammation. Vanin's enzymatic activity is of key importance in certain diseases, either for its protective effect or as a sensitizer, depending on the diseased organ. But vanin-1's primary function is the recycling of pantothenic acid (vitamin B5), an important precursor in the biosynthesis of coenzymeA (CoA). Vanin 1 also plays a role in the regulation of a number of metabolic pathways. Gene vnn1 directly regulates PPAR-alpha mRNA expression in gut epithelial. Vanin 1 is an activator of hepatic gluconeogenesis in mice. Role of vanin 1 in diseases of organs in which it is highly expressed (liver, kidney, intestine, lung), detailed overview Mus musculus