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Literature summary for 3.5.1.92 extracted from
- Vanin 1 its physiological function and role in diseases (2019), Int. J. Mol. Sci., 20, 3891 .
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | bound | Homo sapiens | 16020 | - |
| additional information | vanin 1 is membrane-associated via a glycosylphosphatidylinositol (GPI)-anchor, though soluble enzyme forms are detected as well | Homo sapiens | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (R)-pantetheine + H2O | Homo sapiens | - |
(R)-pantothenate + 2-aminoethanethiol | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O95497 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| hepatocyte | vanin 1 expression specifically by the centrilobular hepatocytes in zone 3 adjacent to the central vein | Homo sapiens | - |
| intestine | - |
Homo sapiens | - |
| kidney | - |
Homo sapiens | - |
| liver | - |
Homo sapiens | - |
| lung | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (R)-pantetheine + H2O | - |
Homo sapiens | (R)-pantothenate + 2-aminoethanethiol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| vanin 1 | - |
Homo sapiens |
| vascular non-inflammatory molecule-1 | - |
Homo sapiens |
| VNN1 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | formation of pantothenic acid allows for a continuous production of CoA, as pantothenic acid is a structural component of this cofactor. In addition, pantothenic acid appears to have profibrotic effects, being involved in the promotion of proliferation and migration of dermal fibroblasts. Moreover, pantothenic acid contributes to restoring CoA levels in the mitochondria, resulting in enhanced mitochondrial activity. Vanin 1 also plays a role in the regulation of a number of metabolic pathways | Homo sapiens |
| physiological function | vanin 1 breaks down pantetheine in cysteamine and pantothenic acid, a precursor of coenzyme A. Its physiological role is not strictly related to coenzyme A metabolism, lipid metabolism, and energy production. It also plays a role under physiological conditions in relation to oxidative stress and inflammation. Vanin's enzymatic activity is of key importance in certain diseases, either for its protective effect or as a sensitizer, depending on the diseased organ. But vanin-1's primary function is the recycling of pantothenic acid (vitamin B5), an important precursor in the biosynthesis of coenzymeA (CoA). Vanin 1 also plays a role in the regulation of a number of metabolic pathways. Role of vanin 1 in diseases of organs in which it is highly expressed (liver, kidney, intestine, lung), detailed overview | Homo sapiens |
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Release 2023.1 (January 2023)
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