Literature summary for 3.5.1.92 extracted from

Ferreira, D.W.; Naquet, P.; Manautou, J.E.
Influence of vanin-1 and catalytic products in liver during normal and oxidative stress conditions (2015), Curr. Med. Chem., 22, 2407-2416 .

Search for more literature for 3.5.1.92

Cloned(Commentary)

Cloned (Comment)	Organism
gene Vnn1	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	construction of Vnn1 knockout mice	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cell surface	pantetheinase is an ectoenzyme that is attached to the outer plasma membrane by a glycosylphosphatidylinositol (GPI) anchor. GPI anchors consist of three domains: a phosphoethanolamine linker that attaches to the C terminal end of the target protein, a conserved glycan core and a phospholipid tail for anchoring to the lipid membrane	Mus musculus	9986	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
(R)-pantetheine + H2O	Mus musculus	-	(R)-pantothenate + 2-aminoethanethiol	-	?
(R)-pantetheine + H2O	Mus musculus C57BL/6	-	(R)-pantothenate + 2-aminoethanethiol	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q9Z0K8	-	-
Mus musculus C57BL/6	Q9Z0K8	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(R)-pantetheine + H2O	-	Mus musculus	(R)-pantothenate + 2-aminoethanethiol	-	?
(R)-pantetheine + H2O	-	Mus musculus C57BL/6	(R)-pantothenate + 2-aminoethanethiol	-	?

Synonyms

Synonyms	Comment	Organism
pantetheinase	-	Mus musculus

Expression

Organism	Comment	Expression
Mus musculus	expression of pantetheinase is controlled by the Vnn1 gene and is upregulated in response to free fatty acids, PPAR activation or oxidative stress. PPARalpha-mediated upregulation of Vnn1 translates to enhanced pantetheinase activity in vivo	up

General Information

General Information	Comment	Organism
metabolism	the availability of free cysteamine is also regulated by hydrolysis of pantetheine by pantetheinase. This cleavage results in the formation of pantothenic acid, a precursor to coenzyme A which is prominently involved with lipid metabolism and energy production by the beta-oxidation pathway and TCA cycle, respectively. Expression of pantetheinase is controlled by the Vnn1 gene and is upregulated in response to free fatty acids, PPAR activation or oxidative stress. Vanin-1 is believed to be the primary transcript responsible for pantetheinase activity. Successful attachment of GPI following its synthesis in the endoplasmic reticulum (ER) requires two signal sequences within the protein. The first is an N terminal signal peptide (amino acids 1-21 of human pantetheinase) that retains the target protein within the ER lumen. The second necessary sequence is a C-terminal 22 amino acid propeptide downstream of the Gly491 residue, termed the omega site, which is removed and replaced by the GPI anchor. This process is mediated by a GPI-transamidase complex composed mainly of members of the phosphatidylinositol glycan (PIG) family, including PIG-K, the catalytic subunit	Mus musculus
physiological function	pantetheinase hydrolyzes pantetheine to pantothenic acid (Vitamin B5) in a reaction that cleaves cysteamine from the pantetheine molecule. Pantetheinase activity regulates the availability of pantothenic acid and cysteamine which are involved in several critical pathways of cell homeostasis including lipid catabolism, synthesis of cholesterol, taurine and NADH as well as maintenance of cellular redox balance. Vascular non-inflammatory molecule 1 (Vanin 1 or Vnn1) modulates redox and immune pathways in vivo, both of which appear at least partially due to a loss of cysteamine/cystamine. Vnn1 expression may influence cell signaling indirectly through maintenance of disulfide bonds or directly by interaction with pantetheinase on the cell surface. Involvement of vanin-1 and pantetheinase in liver homeostasis. Pantetheinase activity can directly influence lipid metabolism, the effects are due to decreased availability of pantothenic acid, resulting in suppression of CoA activity. Pantetheinase likely acts as a regulator of CoA-dependent metabolism by controlling the availability of pantothenic acid in liver. Pantetheinase-mediated catalysis is the main source of endogenous cysteamine in mice. Pantetheinase activity might be protective by augmenting the availability of taurine	Mus musculus

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Release 2023.1 (January 2023)