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Literature summary for 3.5.1.92 extracted from

  • Yamashita, N.; Yashiro, M.; Ogawa, H.; Namba, H.; Nosaka, N.; Fujii, Y.; Morishima, T.; Tsukahara, H.; Yamada, M.
    Metabolic pathway catalyzed by Vanin-1 pantetheinase plays a suppressive role in influenza virus replication in human alveolar epithelial A549 cells (2017), Biochem. Biophys. Res. Commun., 489, 466-471 .
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
gene VNN-1, quantitative real-time RT-PCR expression analysis Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular epithelial ectoenzyme Homo sapiens
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-

Organism

Organism UniProt Comment Textmining
Homo sapiens O95497
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-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
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 Homo sapiens
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alveolar carcinoma cell
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 Homo sapiens
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epithelium
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 Homo sapiens
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HeLa cell
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 Homo sapiens
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additional information quantitative expression analysis of VNN-1 in cancer cells Homo sapiens
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Synonyms

Synonyms Comment Organism
pantetheinase
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 Homo sapiens
vanin-1
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 Homo sapiens
vanin-1 pantetheinase
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 Homo sapiens
vascular noninflammatory molecule 1
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 Homo sapiens
VNN1
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 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the messenger RNA expression of VNN1 in A549 cells is significantly increased (by 4.9fold) after influenza A virus (IAV) infection under an elevated concentration of pantetheine. VNN1 mRNA levels are elevated by over 100fold in response to proinflammatory cytokines, especially TNF-alpha and IL-1beta up

General Information

General Information Comment Organism
physiological function the vanin-1 (vascular noninflammatory molecule 1, VNN1) gene encodes an epithelial ectoenzyme with pantetheinase activity involved in recycling coenzyme A. Pantetheine significantly reduces the IAV replication and influenza A virus (IAV) matrix 1 (M1) mRNA levels when it is administered prior to and during infection. Cysteamine treatment during IAV infection significantly reduces the viral replication and IAV M1 mRNA levels, whereas pantothenic acid does not. The metabolic pathway catalyzed by VNN1 pantetheinase plays a suppressive role in IAV infection in the respiratory tract, especially in severe conditions under hypercytokinemia Homo sapiens