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Literature summary for 3.5.1.92 extracted from

  • Rommelaere, S.; Millet, V.; Rihet, P.; Atwell, S.; Helfer, E.; Chasson, L.; Beaumont, C.; Chimini, G.; Sambo, M.d.o. .R.; Viallat, A.; Penha-Goncalves, C.; Galland, F.; Naquet, P.
    Serum pantetheinase/vanin levels regulate erythrocyte homeostasis and severity of malaria (2015), Am. J. Pathol., 185, 3039-3052 .
    View publication on PubMed
Search for more literature for 3.5.1.92

Cloned(Commentary)

Cloned (Comment) Organism
gene Vnn1, quantitative RT-PCR enzyme expression analysis Homo sapiens
gene Vnn1, quantitative RT-PCR enzyme expression analysis Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens O95497 Malaria diagnosed children living in Luanda (Angola) ranging from 6 months to 13 years of age
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Mus musculus Q9Z0K8 mice injected i.p. with 106 Plasmodium berghei ANKA infected red blood cells
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Mus musculus C57BL/6 Q9Z0K8 mice injected i.p. with 106 Plasmodium berghei ANKA infected red blood cells
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Source Tissue

Source Tissue Comment Organism Textmining
serum
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 Homo sapiens
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serum
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 Mus musculus
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 comparisons of healthy with Malaria red blood cells Homo sapiens
additional information
-
 comparisons of healthy with Malaria red blood cells Mus musculus

Synonyms

Synonyms Comment Organism
pantetheinase
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 Homo sapiens
pantetheinase
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 Mus musculus
VNN1
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 Homo sapiens
VNN1
-
 Mus musculus

General Information

General Information Comment Organism
malfunction mutant mice with a reduced serum pantetheinase activity are anemic and prone to phenylhydrazine-induced anemia. A cytofluorometric and spectroscopic analysis documents an increased frequency of erythrocytes with an autofluorescent aging phenotype. This is associated with an enhanced oxidative stress and shear stress-induced hemolysis. Red blood cell transfer and bone marrow chimera experiments show that the aging phenotype is not cell intrinsic but conferred by the environment, leading to a shortening of red blood cell half-life. Phenotype analysis, detailed overview Mus musculus
metabolism Malaria enzyme phenotype analysis, detailed overview Homo sapiens
physiological function tissue pantetheinase, encoded by the VNN1 gene, regulates response to stress. VNN genes contribute to the susceptibility to malaria. Serum pantetheinase contributes to erythrocyte resistance to stress under homeostatic conditions. Serum pantetheinase level regulates erythrocyte life span and modulates the risk of developing complicated malaria Homo sapiens
physiological function tissue pantetheinase, encoded by the VNN1 gene, regulates response to stress. VNN genes contribute to the susceptibility to malaria. Serum pantetheinase contributes to erythrocyte resistance to stress under homeostatic conditions. Serum pantetheinase level regulates erythrocyte life span and modulates the risk of developing complicated malaria Mus musculus