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Literature summary for 3.5.1.9 extracted from
- Formamidase - Untersuchungen zu Mikroheterogenitt, katalytischen Eigenschaften und Inhibitoren (1979), Hoppe-Seyler's Z. Physiol. Chem., 360, 185-196.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| anthranilic acid | Ki: 1.6 mM | Rattus sp. |  |
| diethyl-(4-nitrophenyl)-phosphate | marked inhibition | Rattus sp. | |
| L-kynurenine | 15% inhibition at 0.1 mM, Ki: 0.25 mM | Rattus sp. | |
| N-bromosuccinimide | marked inhibition | Rattus sp. | |
| Na-Metaarsenite | marked inhibition | Rattus sp. | |
| NaAsO2 | marked inhibition | Rattus sp. | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.06 | - |
N-formyl-L-kynurenine | - |
Rattus sp. | |
| 0.57 | - |
N-formylanthranilic acid | - |
Rattus sp. | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 34900 | - |
SDS-PAGE | Rattus sp. |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N-formyl-L-kynurenine + H2O | Rattus sp. | - |
L-kynurenine + formate | - |
? | |
| N-formylanthranilic acid + H2O | Rattus sp. | - |
formate + anthranilic acid | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus sp. | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| near homogeneity, chromatography techniques, isoelectric focusing | Rattus sp. |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus sp. | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 346 | - |
- |
Rattus sp. |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (2-nitrophenyl)acetate + H2O | - |
Rattus sp. | 2-nitrophenol + acetic acid | - |
? | |
| N-formyl-L-kynurenine + H2O | - |
Rattus sp. | L-kynurenine + formate | - |
? | |
| N-formylanthranilic acid + H2O | - |
Rattus sp. | formate + anthranilic acid | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6 | 9 | - |
Rattus sp. |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.25 | - |
L-kynurenine | - |
Rattus sp. | |
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