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Literature summary for 3.5.1.78 extracted from

  • Chong, C.; Gao, S.; Chiang, B.; Hsu, W.; Lin, T.; Chen, T.; Lin, C.
    An acyloxymethyl ketone-based probe to monitor the activity of glutathionylspermidine amidase in Escherichia coli (2011), ChemBioChem, 12, 2306-2309.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Escherichia coli

Protein Variants

Protein Variants Comment Organism
C59A inactive Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
H2O2
-
Escherichia coli
L-gamma-glutamyl-5-azido-N-(3-[[(4-methylphenyl)sulfonyl]oxy]-2-oxopropyl)-L-norleucinamide
-
Escherichia coli
L-gamma-glutamyl-5-azido-N-[3-(benzoyloxy)-2-oxopropyl]-L-norleucinamide
-
Escherichia coli
L-gamma-glutamyl-N-[3-(benzoyloxy)-2-oxopropyl]-6-[4-([[5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoyl]amino]methyl)-1H-1,2,3-triazol-1-yl]-L-norleucinamide
-
Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli P0AES0 bifunctional glutathionylspermidine synthetase/amidase
-

Synonyms

Synonyms Comment Organism
GSP amidase
-
Escherichia coli
Gsp synthetase/amidase
-
Escherichia coli
GspA glutathionylspermidine amidase domain of Gsp synthetase/amidase Escherichia coli
GspSA
-
Escherichia coli

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00068
-
pH and temperature not specified in the publication Escherichia coli L-gamma-glutamyl-5-azido-N-[3-(benzoyloxy)-2-oxopropyl]-L-norleucinamide
0.00075
-
pH and temperature not specified in the publication Escherichia coli L-gamma-glutamyl-5-azido-N-(3-[[(4-methylphenyl)sulfonyl]oxy]-2-oxopropyl)-L-norleucinamide
0.00217
-
pH and temperature not specified in the publication Escherichia coli L-gamma-glutamyl-5-azido-N-(3-[[(4-methylphenyl)sulfonyl]oxy]-2-oxopropyl)-L-norleucinamide