Literature summary for 3.5.1.6 extracted from

Fidlerova, J.; Kleiblova, P.; Kormunda, S.; Novotny, J.; Kleibl, Z.
Contribution of the beta-ureidopropionase (UPB1) gene alterations to the development of fluoropyrimidine-related toxicity (2012), Pharmacol. Rep., 64, 1234-1242.

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Cloned(Commentary)

Cloned (Comment)	Organism
gene UPB1, DNA and amino acid sequence determination and analysis, genotyping, reverse transcription and quantitative real-time PCR enzyme expression analysis, overview	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9UBR1	gene UPB1	-

Synonyms

Synonyms	Comment	Organism
BUP1	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	enzyme mutational analysis: association between the c.-80C>G (rs2070474) genetic enzyme variant and gastrointestinal toxicity, strong positive correlation between the carriers of the c.-80GG genotype and the development of severe (grade 3-4) mucositis. Gene UPB1 variants may contribute to the development of 5-fluorouracil-related toxicity in some fluoropyrimidine-treated patients, but with less importance that the alterations in the dihydropyrimidine dehydrogenase (EC 1.3.1.2) gene	Homo sapiens
metabolism	the beta-ureidopropionase enzyme catalyzes the final step in the 5-fluorouracil catabolic pathway	Homo sapiens

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Release 2023.1 (January 2023)