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Literature summary for 3.5.1.5 extracted from

  • Feder, V.; Kmetzsch, L.; Staats, C.C.; Vidal-Figueiredo, N.; Ligabue-Braun, R.; Carlini, C.R.; Vainstein, M.H.
    Cryptococcus gattii urease as a virulence factor and the relevance of enzymatic activity in cryptococcosis pathogenesis (2015), FEBS J., 282, 1406-1418 .
    View publication on PubMed
Search for more literature for 3.5.1.5

Application

Application Comment Organism
medicine importance of overall cryptococcal urease inhibition, rather than of its enzymatic activity alone, for the future development of therapeutic tools targeting cryptococcosis Cryptococcus gattii VGI

Metals/Ions

Metals/Ions Comment Organism Structure
Ni2+ Ni2+-dependent metalloenzyme Cryptococcus gattii VGI

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
urea + H2O Cryptococcus gattii VGI
-
 CO2 + 2 NH3
-
 ?
urea + H2O Cryptococcus gattii VGI R265
-
 CO2 + 2 NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Cryptococcus gattii VGI Q2QEI4 hypervirulent strain R265, serotype B, mating type alpha
-
Cryptococcus gattii VGI R265 Q2QEI4 hypervirulent strain R265, serotype B, mating type alpha
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
urea + H2O
-
 Cryptococcus gattii VGI CO2 + 2 NH3
-
 ?
urea + H2O
-
 Cryptococcus gattii VGI R265 CO2 + 2 NH3
-
 ?

General Information

General Information Comment Organism
physiological function Cryptococcus gattii urease plays an important role in virulence, in part possibly through enzyme activity-independent mechanism(s) Cryptococcus gattii VGI