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Literature summary for 3.5.1.5 extracted from

  • Khan, K.; Rahim, F.; Khan, A.; Shabeer, M.; Hussain, S.; Rehman, W.; Taha, M.; Khan, M.; Perveen, S.; Choudhary, M.
    Synthesis and structure-activity relationship of thiobarbituric acid derivatives as potent inhibitors of urease (2014), Bioorg. Med. Chem., 22, 4119-4123.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-thioxo-5-(2,3,4-trihydroxybenzylidene)dihydro-4,6(1H,5H)-pyrimidinedione
-
Sporosarcina pasteurii
5-(1,4-dihydro-9-anthracenylmethylene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
-
Sporosarcina pasteurii
5-(1H-indol-3-ylmethylene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
-
Sporosarcina pasteurii
5-(2,4-dihydroxybenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
-
Sporosarcina pasteurii
5-(2-aminobenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
-
Sporosarcina pasteurii
5-(2-bromo-4,5-dimethoxybenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
-
Sporosarcina pasteurii
5-(2-hydroxy-3-methoxybenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
-
Sporosarcina pasteurii
5-(2-hydroxy-5-methoxybenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
-
Sporosarcina pasteurii
5-(2-methylbenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
-
Sporosarcina pasteurii
5-(2-thienylmethylene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
-
Sporosarcina pasteurii
5-(3,4-dihydroxybenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
-
Sporosarcina pasteurii
5-(3,4-dimethoxybenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
-
Sporosarcina pasteurii
5-(3,5-dibromo-4-hydroxybenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
-
Sporosarcina pasteurii
5-(3,5-dichloro-2-hydroxybenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
-
Sporosarcina pasteurii
5-(3-hydroxy-4-methoxybenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
-
Sporosarcina pasteurii
5-(4-bromo-2,5-dimethoxybenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
-
Sporosarcina pasteurii
5-(4-ethoxybenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
-
Sporosarcina pasteurii
5-(4-hydroxy-3,5-dimethoxybenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
-
Sporosarcina pasteurii
5-(4-hydroxy-3-iodo-5-methoxybenzylidene)-2-thioxodihydro-4,6(1H,5H) pyrimidinedione
-
Sporosarcina pasteurii
5-(4-pyridinylmethylene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
-
Sporosarcina pasteurii
5-(4-[[4,6-dioxo-2-thioxotetrahydro-5(2H)pyrimidinylidene]methyl]-benzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
-
Sporosarcina pasteurii
5-[(2-hydroxy-1-naphthyl)methylene]-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
-
Sporosarcina pasteurii
5-[(5-methyl-2-furyl)methylene]-2-thioxodihydro-4,6(1H,5H)pyrimidinedione
-
Sporosarcina pasteurii
5-[(6-bromo-4-chloro-2-oxo-2H-chromen-3-yl)methylene]-2-thioxodihydro 4,6(1H,5H)-pyrimidinedione
-
Sporosarcina pasteurii
5-[(6-methyl-2-pyridinyl)methylene]-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
-
Sporosarcina pasteurii
5-[4(dimethylamino) benzylidene]-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
-
Sporosarcina pasteurii
5-[4-(methylsulfanyl)benzylidene]-2-thioxodihydro-4,6(1H,5H) pyrimidinedione
-
Sporosarcina pasteurii
additional information synthesis and structure-activity relationship of thiobarbituric acid derivatives as potent inhibitors of urease, overview Sporosarcina pasteurii
Thiourea
-
Sporosarcina pasteurii

Organism

Organism UniProt Comment Textmining
Sporosarcina pasteurii
-
-
-

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Sporosarcina pasteurii

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00161
-
pH not specified in the publication, 30°C Sporosarcina pasteurii 5-(3,4-dihydroxybenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
0.0067
-
pH not specified in the publication, 30°C Sporosarcina pasteurii 5-(4-[[4,6-dioxo-2-thioxotetrahydro-5(2H)pyrimidinylidene]methyl]-benzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
0.0106
-
pH not specified in the publication, 30°C Sporosarcina pasteurii 5-(3,5-dibromo-4-hydroxybenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
0.0143
-
pH not specified in the publication, 30°C Sporosarcina pasteurii 5-(3,4-dimethoxybenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
0.016
-
pH not specified in the publication, 30°C Sporosarcina pasteurii 5-(4-pyridinylmethylene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
0.016
-
pH not specified in the publication, 30°C Sporosarcina pasteurii 5-[(6-methyl-2-pyridinyl)methylene]-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
0.0181
-
pH not specified in the publication, 30°C Sporosarcina pasteurii 5-[4-(methylsulfanyl)benzylidene]-2-thioxodihydro-4,6(1H,5H) pyrimidinedione
0.0182
-
pH not specified in the publication, 30°C Sporosarcina pasteurii 5-[(5-methyl-2-furyl)methylene]-2-thioxodihydro-4,6(1H,5H)pyrimidinedione
0.0192
-
pH not specified in the publication, 30°C Sporosarcina pasteurii 5-(2-hydroxy-3-methoxybenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
0.021
-
pH not specified in the publication, 30°C Sporosarcina pasteurii Thiourea
0.0214
-
pH not specified in the publication, 30°C Sporosarcina pasteurii 5-[(2-hydroxy-1-naphthyl)methylene]-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
0.0215
-
pH not specified in the publication, 30°C Sporosarcina pasteurii 5-(2-thienylmethylene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
0.0228
-
pH not specified in the publication, 30°C Sporosarcina pasteurii 5-(3-hydroxy-4-methoxybenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
0.0252
-
pH not specified in the publication, 30°C Sporosarcina pasteurii 2-thioxo-5-(2,3,4-trihydroxybenzylidene)dihydro-4,6(1H,5H)-pyrimidinedione
0.0294
-
pH not specified in the publication, 30°C Sporosarcina pasteurii 5-(4-ethoxybenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
0.0321
-
pH not specified in the publication, 30°C Sporosarcina pasteurii 5-(2,4-dihydroxybenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
0.0323
-
pH not specified in the publication, 30°C Sporosarcina pasteurii 5-(2-aminobenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
0.0327
-
pH not specified in the publication, 30°C Sporosarcina pasteurii 5-(2-hydroxy-5-methoxybenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
0.0421
-
pH not specified in the publication, 30°C Sporosarcina pasteurii 5-(2-methylbenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
0.0425
-
pH not specified in the publication, 30°C Sporosarcina pasteurii 5-(4-hydroxy-3-iodo-5-methoxybenzylidene)-2-thioxodihydro-4,6(1H,5H) pyrimidinedione
0.0433
-
pH not specified in the publication, 30°C Sporosarcina pasteurii 5-(4-bromo-2,5-dimethoxybenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
0.0465
-
pH not specified in the publication, 30°C Sporosarcina pasteurii 5-(4-hydroxy-3,5-dimethoxybenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
0.0473
-
pH not specified in the publication, 30°C Sporosarcina pasteurii 5-(2-bromo-4,5-dimethoxybenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
0.0503
-
pH not specified in the publication, 30°C Sporosarcina pasteurii 5-(3,5-dichloro-2-hydroxybenzylidene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
0.0585
-
pH not specified in the publication, 30°C Sporosarcina pasteurii 5-[4(dimethylamino) benzylidene]-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
0.0628
-
pH not specified in the publication, 30°C Sporosarcina pasteurii 5-[(6-bromo-4-chloro-2-oxo-2H-chromen-3-yl)methylene]-2-thioxodihydro 4,6(1H,5H)-pyrimidinedione
0.1372
-
pH not specified in the publication, 30°C Sporosarcina pasteurii 5-(1,4-dihydro-9-anthracenylmethylene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
0.1708
-
pH not specified in the publication, 30°C Sporosarcina pasteurii 5-(1H-indol-3-ylmethylene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione