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Literature summary for 3.5.1.5 extracted from

  • Tarun, E.; Zheldakova, T.; Metelitza, D.
    Substituted 1,5,6,7-tetrahydro-4H-benzimidazol-4-ones as urease inhibitors (2009), Biochemistry (Moscow) Suppl. Ser. B, 3, 71-76.
No PubMed abstract available
Search for more literature for 3.5.1.5

Inhibitors

Inhibitors Comment Organism Structure
1-benzyl-2-ethyl-6,6-dimethyl-1,5,6,7-tetrahydro-4H-benzimidazol-4-one reversible and competitive inhibitor Glycine max
1-benzyl-2-ethyl-6-(2,4,6-trimethylphenyl)-1,5,6,7-tetrahydro-4H-benzimidazol-4-one reversible and competitive inhibitor Glycine max
1-ethoxy-2-ethyl-6,6-dimethyl-1,5,6,7-tetrahydro-4H-benzimidazol-4-one reversible and competitive inhibitor Glycine max
1-ethoxy-2-ethyl-6-(2,4,6-trimethylphenyl)-1,5,6,7-tetrahydro-4H-benzimidazol-4-one reversible and competitive inhibitor Glycine max
2-ethyl-1-(2-phenylethyl)-6-(2,4,6-trimethylphenyl)-1,5,6,7-tetrahydro-4H-benzimidazol-4-one reversible and competitive inhibitor Glycine max
2-ethyl-1-(4-methoxycyclohexyl)-6,6-dimethyl-1,5,6,7-tetrahydro-4H-benzimidazol-4-one reversible and competitive inhibitor Glycine max
2-ethyl-1-(4-methoxyphenyl)-6-(2,4,6-trimethylphenyl)-1,5,6,7-tetrahydro-4H-benzimidazol-4-one reversible and competitive inhibitor Glycine max
2-ethyl-6-[2-(ethylsulfanyl)propyl]-1-(4-methoxyphenyl)-1,5,6,7-tetrahydro-4H-benzimidazol-4-one reversible and competitive inhibitor Glycine max

Organism

Organism UniProt Comment Textmining
Glycine max
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
urea + H2O
-
 Glycine max CO2 + NH3
-
 ?

Synonyms

Synonyms Comment Organism
urease
-
 Glycine max

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
36
-
 assay at Glycine max

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
3.85
-
 assay at Glycine max

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0293
-
 2-ethyl-1-(4-methoxycyclohexyl)-6,6-dimethyl-1,5,6,7-tetrahydro-4H-benzimidazol-4-one pH 3.85, 36°C Glycine max
0.0495
-
 2-ethyl-1-(4-methoxyphenyl)-6-(2,4,6-trimethylphenyl)-1,5,6,7-tetrahydro-4H-benzimidazol-4-one pH 3.85, 36°C Glycine max
0.0817
-
 2-ethyl-6-[2-(ethylsulfanyl)propyl]-1-(4-methoxyphenyl)-1,5,6,7-tetrahydro-4H-benzimidazol-4-one pH 3.85, 36°C Glycine max
0.106
-
 1-benzyl-2-ethyl-6-(2,4,6-trimethylphenyl)-1,5,6,7-tetrahydro-4H-benzimidazol-4-one pH 3.85, 36°C Glycine max
0.169
-
 2-ethyl-1-(2-phenylethyl)-6-(2,4,6-trimethylphenyl)-1,5,6,7-tetrahydro-4H-benzimidazol-4-one pH 3.85, 36°C Glycine max
0.358
-
 1-benzyl-2-ethyl-6,6-dimethyl-1,5,6,7-tetrahydro-4H-benzimidazol-4-one pH 3.85, 36°C Glycine max
0.446
-
 1-ethoxy-2-ethyl-6,6-dimethyl-1,5,6,7-tetrahydro-4H-benzimidazol-4-one pH 3.85, 36°C Glycine max
0.566
-
 1-ethoxy-2-ethyl-6-(2,4,6-trimethylphenyl)-1,5,6,7-tetrahydro-4H-benzimidazol-4-one pH 3.85, 36°C Glycine max
0.754
-
 1-benzyl-2-ethyl-6-(2,4,6-trimethylphenyl)-1,5,6,7-tetrahydro-4H-benzimidazol-4-one pH 3.85, 36°C Glycine max