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Literature summary for 3.5.1.5 extracted from
- Edwardsiella ictaluri encodes an acid-activated urease that is required for intracellular replication in channel catfish (Ictalurus punctatus) macrophages (2009), Appl. Environ. Microbiol., 75, 6712-6720.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Edwardsiella ictaluri | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| urea + H2O | - |
Edwardsiella ictaluri | CO2 + NH3 | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| urease | - |
Edwardsiella ictaluri |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 28 | - |
assay at | Edwardsiella ictaluri |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 2 | 3 | optimal activity | Edwardsiella ictaluri |
| 5 | 7 | proteomic analysis with two-dimensional gel electrophoresis shows that urease proteins are expressed at both pH 5 and pH 7, although urease activity is detectable only when urease is grown at pH 5 | Edwardsiella ictaluri |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | growth studies demonstrate that Edwardsiella ictaluri is unable to grow at pH 5 in the absence of urea but is able to elevate the environmental pH from pH 5 to pH 7 and grow when exogenous urea is available | Edwardsiella ictaluri |
| physiological function | urease is required for proliferation and virulence and for intracellular replication. Intracellular replication of wild-type Edwardsiella ictaluri is significantly enhanced when urea is present, indicating that urease plays an important role in intracellular survival and replication, possibly through neutralization of the acidic environment of the phagosome | Edwardsiella ictaluri |
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Release 2023.1 (January 2023)
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