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Literature summary for 3.5.1.5 extracted from

  • Vassiliou, S.; Grabowiecka, A.; Kosikowska, P.; Yiotakis, A.; Kafarski, P.; Berlicki, L.
    Design, synthesis, and evaluation of novel organophosphorus inhibitors of bacterial ureases (2008), J. Med. Chem., 51, 5736-5744.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
([[(benzyloxy)carbonyl]amino]methyl)methylphosphinothioic O-acid
-
Proteus vulgaris
([[(benzyloxy)carbonyl]amino]methyl)methylphosphinothioic O-acid
-
Sporosarcina pasteurii
aminomethyl(P-methyl)phosphinic acid
-
Proteus vulgaris
aminomethyl(P-methyl)phosphinic acid
-
Sporosarcina pasteurii
methyl[(methylamino)methyl]phosphinic acid
-
Proteus vulgaris
methyl[(methylamino)methyl]phosphinic acid
-
Sporosarcina pasteurii
N-(N'-benzyloxycarbonylglycyl)aminomethyl(P-methyl)phosphinothioic acid
-
Proteus vulgaris
N-(N'-benzyloxycarbonylglycyl)aminomethyl(P-methyl)phosphinothioic acid
-
Sporosarcina pasteurii
N-benzyloxycarbonylaminomethyl(P-methyl)phosphinic acid
-
Proteus vulgaris
N-benzyloxycarbonylaminomethyl(P-methyl)phosphinic acid
-
Sporosarcina pasteurii
N-glycyl-aminomethyl(P-methyl)phosphinic acid
-
Proteus vulgaris
N-glycyl-aminomethyl(P-methyl)phosphinic acid
-
Sporosarcina pasteurii
N-[[hydroxy(methyl)phosphoryl]methyl]-L-phenylalaninamide
-
Proteus vulgaris
N-[[hydroxy(methyl)phosphoryl]methyl]-L-phenylalaninamide
-
Sporosarcina pasteurii
N-[[hydroxy(methyl)phosphoryl]methyl]-L-serinamide
-
Proteus vulgaris
N-[[hydroxy(methyl)phosphoryl]methyl]-L-serinamide
-
Sporosarcina pasteurii
N-[[hydroxy(methyl)phosphoryl]methyl]-L-valinamide
-
Proteus vulgaris
N-[[hydroxy(methyl)phosphoryl]methyl]-L-valinamide
-
Sporosarcina pasteurii
N2-[(benzyloxy)carbonyl]-N-[[hydroxy(methyl)phosphoryl]methyl]glycinamide
-
Proteus vulgaris
N2-[(benzyloxy)carbonyl]-N-[[hydroxy(methyl)phosphoryl]methyl]glycinamide
-
Sporosarcina pasteurii
O-benzyl-N-[[hydroxy(methyl)phosphoryl]methyl]-L-serinamide
-
Proteus vulgaris
O-benzyl-N-[[hydroxy(methyl)phosphoryl]methyl]-L-serinamide
-
Sporosarcina pasteurii

Organism

Organism UniProt Comment Textmining
Proteus vulgaris
-
CCM 1956
-
Proteus vulgaris CCM 1956
-
CCM 1956
-
Sporosarcina pasteurii
-
CCM 2056
-
Sporosarcina pasteurii CCM 2056
-
CCM 2056
-

Purification (Commentary)

Purification (Comment) Organism
-
Proteus vulgaris
-
Sporosarcina pasteurii

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
urea + H2O
-
Proteus vulgaris CO2 + 2 NH3
-
?
urea + H2O
-
Sporosarcina pasteurii CO2 + 2 NH3
-
?
urea + H2O
-
Proteus vulgaris CCM 1956 CO2 + 2 NH3
-
?
urea + H2O
-
Sporosarcina pasteurii CCM 2056 CO2 + 2 NH3
-
?

Synonyms

Synonyms Comment Organism
Urea amidohydrolase
-
Proteus vulgaris
Urea amidohydrolase
-
Sporosarcina pasteurii
urease
-
Proteus vulgaris
urease
-
Sporosarcina pasteurii

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00017
-
N-(N'-benzyloxycarbonylglycyl)aminomethyl(P-methyl)phosphinothioic acid
-
Sporosarcina pasteurii
0.00045
-
N-(N'-benzyloxycarbonylglycyl)aminomethyl(P-methyl)phosphinothioic acid
-
Proteus vulgaris
0.014
-
([[(benzyloxy)carbonyl]amino]methyl)methylphosphinothioic O-acid
-
Proteus vulgaris
0.0175
-
([[(benzyloxy)carbonyl]amino]methyl)methylphosphinothioic O-acid
-
Sporosarcina pasteurii
0.018
-
methyl[(methylamino)methyl]phosphinic acid
-
Sporosarcina pasteurii
0.021
-
N-glycyl-aminomethyl(P-methyl)phosphinic acid
-
Sporosarcina pasteurii
0.025
-
O-benzyl-N-[[hydroxy(methyl)phosphoryl]methyl]-L-serinamide
-
Sporosarcina pasteurii
0.027
-
methyl[(methylamino)methyl]phosphinic acid
-
Proteus vulgaris
0.03
-
N-glycyl-aminomethyl(P-methyl)phosphinic acid
-
Proteus vulgaris
0.0326
-
O-benzyl-N-[[hydroxy(methyl)phosphoryl]methyl]-L-serinamide
-
Proteus vulgaris
0.037
-
N-[[hydroxy(methyl)phosphoryl]methyl]-L-serinamide
-
Sporosarcina pasteurii
0.041
-
N-[[hydroxy(methyl)phosphoryl]methyl]-L-serinamide
-
Proteus vulgaris
0.043
-
N-benzyloxycarbonylaminomethyl(P-methyl)phosphinic acid
-
Sporosarcina pasteurii
0.065
-
N-benzyloxycarbonylaminomethyl(P-methyl)phosphinic acid
-
Proteus vulgaris
0.12
-
N-[[hydroxy(methyl)phosphoryl]methyl]-L-valinamide
-
Sporosarcina pasteurii
0.135
-
N2-[(benzyloxy)carbonyl]-N-[[hydroxy(methyl)phosphoryl]methyl]glycinamide
-
Sporosarcina pasteurii
0.176
-
N-[[hydroxy(methyl)phosphoryl]methyl]-L-phenylalaninamide
-
Proteus vulgaris
0.178
-
N2-[(benzyloxy)carbonyl]-N-[[hydroxy(methyl)phosphoryl]methyl]glycinamide
-
Proteus vulgaris
0.208
-
N-[[hydroxy(methyl)phosphoryl]methyl]-L-valinamide
-
Proteus vulgaris
0.215
-
N-[[hydroxy(methyl)phosphoryl]methyl]-L-phenylalaninamide
-
Sporosarcina pasteurii
0.34
-
aminomethyl(P-methyl)phosphinic acid
-
Sporosarcina pasteurii
0.425
-
aminomethyl(P-methyl)phosphinic acid
-
Proteus vulgaris

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0018
-
-
Sporosarcina pasteurii N-(N'-benzyloxycarbonylglycyl)aminomethyl(P-methyl)phosphinothioic acid
0.0031
-
-
Proteus vulgaris N-(N'-benzyloxycarbonylglycyl)aminomethyl(P-methyl)phosphinothioic acid
0.06
-
-
Sporosarcina pasteurii methyl[(methylamino)methyl]phosphinic acid
0.06
-
-
Sporosarcina pasteurii N-glycyl-aminomethyl(P-methyl)phosphinic acid
0.08
-
-
Sporosarcina pasteurii O-benzyl-N-[[hydroxy(methyl)phosphoryl]methyl]-L-serinamide
0.086
-
-
Proteus vulgaris N-glycyl-aminomethyl(P-methyl)phosphinic acid
0.112
-
-
Sporosarcina pasteurii ([[(benzyloxy)carbonyl]amino]methyl)methylphosphinothioic O-acid
0.123
-
-
Sporosarcina pasteurii N-benzyloxycarbonylaminomethyl(P-methyl)phosphinic acid
0.15
-
-
Sporosarcina pasteurii N-[[hydroxy(methyl)phosphoryl]methyl]-L-serinamide
0.153
-
-
Proteus vulgaris methyl[(methylamino)methyl]phosphinic acid
0.158
-
-
Proteus vulgaris ([[(benzyloxy)carbonyl]amino]methyl)methylphosphinothioic O-acid
0.183
-
-
Proteus vulgaris O-benzyl-N-[[hydroxy(methyl)phosphoryl]methyl]-L-serinamide
0.319
-
-
Proteus vulgaris N-benzyloxycarbonylaminomethyl(P-methyl)phosphinic acid
0.342
-
-
Proteus vulgaris N-[[hydroxy(methyl)phosphoryl]methyl]-L-serinamide
0.45
-
-
Sporosarcina pasteurii N2-[(benzyloxy)carbonyl]-N-[[hydroxy(methyl)phosphoryl]methyl]glycinamide
0.485
-
-
Sporosarcina pasteurii N-[[hydroxy(methyl)phosphoryl]methyl]-L-valinamide
0.6
-
-
Sporosarcina pasteurii N-[[hydroxy(methyl)phosphoryl]methyl]-L-phenylalaninamide
0.617
-
-
Proteus vulgaris N-[[hydroxy(methyl)phosphoryl]methyl]-L-valinamide
0.64
-
-
Proteus vulgaris N2-[(benzyloxy)carbonyl]-N-[[hydroxy(methyl)phosphoryl]methyl]glycinamide
0.754
-
-
Proteus vulgaris N-[[hydroxy(methyl)phosphoryl]methyl]-L-phenylalaninamide
1.1
-
-
Sporosarcina pasteurii aminomethyl(P-methyl)phosphinic acid
2.53
-
-
Proteus vulgaris aminomethyl(P-methyl)phosphinic acid