Literature summary for 3.5.1.5 extracted from

Ansari, F.L.; Wadood, A.; Ullah, A.; Iftikhar, F.; Ul-Haq, Z.
In silico studies of urease inhibitors to explore ligand-enzyme interactions (2009), J. Enzyme Inhib. Med. Chem., 24, 151-156.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(2E)-3-(1,3-benzodioxol-5-yl)-1-(2-hydroxyphenyl)prop-2-en-1-one	-	Canavalia ensiformis
2,4-diphenyl-2,3-dihydro-1,5-benzothiazepine	-	Canavalia ensiformis
2-(4-methylphenyl)-4-phenyl-2,3-dihydro-1,5-benzothiazepine	-	Canavalia ensiformis
2-(4-nitrophenyl)-4-phenyl-2,3-dihydro-1,5-benzothiazepine	-	Canavalia ensiformis
2-[(2S,4R)-2-(4-fluorophenyl)-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-yl]phenol	-	Canavalia ensiformis
2-[(2S,4R)-2-phenyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-yl]phenol	-	Canavalia ensiformis
2-[2-(1,3-benzodioxol-5-yl)-2,3-dihydro-1,5-benzothiazepin-4-yl]phenol	-	Canavalia ensiformis
Thiourea	-	Canavalia ensiformis

Organism

Organism	UniProt	Comment	Textmining
Canavalia ensiformis	-	Jack bean	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
urea + H2O	-	Canavalia ensiformis	CO2 + 2 NH3	-	?

Synonyms

Synonyms	Comment	Organism
urease	-	Canavalia ensiformis

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.01907	-	-	Canavalia ensiformis	2-[2-(1,3-benzodioxol-5-yl)-2,3-dihydro-1,5-benzothiazepin-4-yl]phenol
0.0211	-	-	Canavalia ensiformis	Thiourea
0.02465	-	-	Canavalia ensiformis	2-(4-methylphenyl)-4-phenyl-2,3-dihydro-1,5-benzothiazepine
0.02631	-	-	Canavalia ensiformis	2,4-diphenyl-2,3-dihydro-1,5-benzothiazepine
0.03251	-	-	Canavalia ensiformis	(2E)-3-(1,3-benzodioxol-5-yl)-1-(2-hydroxyphenyl)prop-2-en-1-one
0.03671	-	-	Canavalia ensiformis	2-(4-nitrophenyl)-4-phenyl-2,3-dihydro-1,5-benzothiazepine
0.09121	-	-	Canavalia ensiformis	2-[(2S,4R)-2-phenyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-yl]phenol
0.09374	-	-	Canavalia ensiformis	2-[(2S,4R)-2-(4-fluorophenyl)-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-yl]phenol

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Release 2023.1 (January 2023)