Literature summary for 3.5.1.5 extracted from

Khan, K.M.; Iqbal, S.; Lodhi, M.A.; Maharvi, G.M.; Ullah, Z.; Choudhary, M.I.; Rahman, A.U.; Perveen, S.
Biscoumarin: new class of urease inhibitors; economical synthesis and activity (2004), Bioorg. Med. Chem., 15, 1963-1968.

Inhibitors

Inhibitors	Comment	Organism
3,3'-(2-bromobenzylidene)-bis-(4-hydroxycoumarin)	-	Canavalia ensiformis
3,3'-(2-chlorobenzylidene)-bis-(4-hydroxycoumarin)	-	Canavalia ensiformis
3,3'-(2-methoxybenzylidene)-bis-(4-hydroxycoumarin)	-	Canavalia ensiformis
3,3'-(2-phenylpropylidene)-bis-(4-hydroxycoumarin)	-	Canavalia ensiformis
3,3'-(2-pyridyl-methylene)-bis-(4-hydroxycoumarin)	-	Canavalia ensiformis
3,3'-(2-pyrolidene)-bis-(4-hydroxycoumarin)	-	Canavalia ensiformis
3,3'-(3-chlorobenzylidene)-bis-(4-hydroxycoumarin)	-	Canavalia ensiformis
3,3'-(3-cinnamylidene)-bis-(4-hydroxycoumarin)	-	Canavalia ensiformis
3,3'-(3-hydroxybenzylidene)-bis-(4-hydroxycoumarin)	-	Canavalia ensiformis
3,3'-(3-indolidene)-bis-(4-hydroxycoumarin)	-	Canavalia ensiformis
3,3'-(3-methoxybenzylidene)-bis-(4-hydroxycoumarin)	-	Canavalia ensiformis
3,3'-(4-hydroxybenzylidene)-bis-(4-hydroxycoumarin)	-	Canavalia ensiformis
3,3'-(4-methoxybenzylidene)-bis-(4-hydroxycoumarin)	-	Canavalia ensiformis
3,3'-(4-nitrobenzylidene)-bis-(4-hydroxycoumarin)	-	Canavalia ensiformis
3,3'-(crotonalidene)-bis-(4-hydroxycoumarin)	-	Canavalia ensiformis
3,3'-(dihydrocinnamylidene)-bis-(4-hydroxycoumarin)	-	Canavalia ensiformis
3,3'-ethylidenebis-(4-hydroxycoumarin)	-	Canavalia ensiformis
3,3'-methylenebis-(4-hydroxycoumarin)	-	Canavalia ensiformis
3,3'-n-butylidene-bis(4-hydroxycoumarin)	-	Canavalia ensiformis
3,3'-n-hexylidene-bis(4-hydroxycoumarin)	-	Canavalia ensiformis
3,3'-n-pentylidene-bis(4-hydroxycoumarin)	-	Canavalia ensiformis
Thiourea	-	Canavalia ensiformis

Organism

Organism	UniProt	Comment	Textmining
Canavalia ensiformis	-	Jack bean	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor
0.01501	-	-	Canavalia ensiformis	3,3'-methylenebis-(4-hydroxycoumarin)
0.021	-	-	Canavalia ensiformis	Thiourea
0.03503	-	-	Canavalia ensiformis	3,3'-(2-pyridyl-methylene)-bis-(4-hydroxycoumarin)
0.04292	-	-	Canavalia ensiformis	3,3'-(crotonalidene)-bis-(4-hydroxycoumarin)
0.04609	-	-	Canavalia ensiformis	3,3'-(2-pyrolidene)-bis-(4-hydroxycoumarin)
0.04841	-	-	Canavalia ensiformis	3,3'-(3-indolidene)-bis-(4-hydroxycoumarin)
0.05218	-	-	Canavalia ensiformis	3,3'-(2-phenylpropylidene)-bis-(4-hydroxycoumarin)
0.0553	-	-	Canavalia ensiformis	3,3'-(4-methoxybenzylidene)-bis-(4-hydroxycoumarin)
0.05906	-	-	Canavalia ensiformis	3,3'-(3-cinnamylidene)-bis-(4-hydroxycoumarin)
0.05978	-	-	Canavalia ensiformis	3,3'-(3-methoxybenzylidene)-bis-(4-hydroxycoumarin)
0.0613	-	-	Canavalia ensiformis	3,3'-ethylidenebis-(4-hydroxycoumarin)
0.06501	-	-	Canavalia ensiformis	3,3'-(4-nitrobenzylidene)-bis-(4-hydroxycoumarin)
0.06639	-	-	Canavalia ensiformis	3,3'-n-butylidene-bis(4-hydroxycoumarin)
0.06728	-	-	Canavalia ensiformis	3,3'-(dihydrocinnamylidene)-bis-(4-hydroxycoumarin)
0.07191	-	-	Canavalia ensiformis	3,3'-(3-hydroxybenzylidene)-bis-(4-hydroxycoumarin)
0.07293	-	-	Canavalia ensiformis	3,3'-(3-chlorobenzylidene)-bis-(4-hydroxycoumarin)
0.07368	-	-	Canavalia ensiformis	3,3'-(4-hydroxybenzylidene)-bis-(4-hydroxycoumarin)
0.07385	-	-	Canavalia ensiformis	3,3'-(2-bromobenzylidene)-bis-(4-hydroxycoumarin)
0.08181	-	-	Canavalia ensiformis	3,3'-(2-methoxybenzylidene)-bis-(4-hydroxycoumarin)
0.08453	-	-	Canavalia ensiformis	3,3'-(2-chlorobenzylidene)-bis-(4-hydroxycoumarin)
0.08474	-	-	Canavalia ensiformis	3,3'-n-pentylidene-bis(4-hydroxycoumarin)
0.08632	-	-	Canavalia ensiformis	3,3'-n-hexylidene-bis(4-hydroxycoumarin)