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Literature summary for 3.5.1.5 extracted from

  • Amtul, Z.; Rasheed, M.; Choudhary, M.I.; Rosanna, S.; Khan, K.M.; Atta Ur, R.
    Kinetics of novel competitive inhibitors of urease enzymes by a focused library of oxadiazoles/thiadiazoles and triazoles (2004), Biochem. Biophys. Res. Commun., 319, 1053-1063.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2,2'-bi-1,3,4-oxadiazole-5,5'(4H,4'H)-dithione pH 8.2, IC50: 0.133 mM Canavalia ensiformis
2,2'-bi-1,3,4-oxadiazole-5,5'(4H,4'H)-dithione pH 8.2, IC50: below 0.125 mM Proteus mirabilis
2,2'-bi-1,3,4-oxadiazole-5,5'(4H,4'H)-dithione
-
Sporosarcina pasteurii
2,2'-bi-1,3,4-thiadiazole-5,5'(4H,4'H)-dithione pH 8.2, IC50: 0.5 mM Proteus mirabilis
2,2'-bi-1,3,4-thiadiazole-5,5'(4H,4'H)-dithione
-
Sporosarcina pasteurii
4-(4-benzoyl-5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)phenyl benzoate pH 8.2, IC50: 0.234 mM Canavalia ensiformis
4-(4-benzoyl-5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)phenyl benzoate
-
Sporosarcina pasteurii
4-amino-5-(4-hydroxyphenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione pH 8.2, IC50: below 0.125 mM Proteus mirabilis
4-amino-5-(4-hydroxyphenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione
-
Sporosarcina pasteurii
4-amino-5-pyridin-4-yl-2,4-dihydro-3H-1,2,4-triazole-3-thione pH 8.2, IC50: 0.163 mM Canavalia ensiformis
4-amino-5-pyridin-4-yl-2,4-dihydro-3H-1,2,4-triazole-3-thione
-
Sporosarcina pasteurii
5-(1-naphthyl)-1,3,4-oxadiazole-2(3H)-thione pH 8.2, IC50: 0.214 mM Canavalia ensiformis
5-(1-naphthyl)-1,3,4-oxadiazole-2(3H)-thione pH 8.2, IC50: below 0.125 mM Proteus mirabilis
5-(1-naphthyl)-1,3,4-oxadiazole-2(3H)-thione
-
Sporosarcina pasteurii
5-(3-hydroxyphenyl)-1,3,4-oxadiazole-2(3H)-thione pH 8.2, IC50: below 0.125 mM Proteus mirabilis
5-(3-hydroxyphenyl)-1,3,4-oxadiazole-2(3H)-thione
-
Sporosarcina pasteurii
5-(4-hydroxyphenyl)-1,3,4-oxadiazole-2(3H)-thione pH 8.2, IC50: 0.5 mM Proteus mirabilis
5-(4-hydroxyphenyl)-1,3,4-oxadiazole-2(3H)-thione
-
Sporosarcina pasteurii
5-(4-hydroxyphenyl)-1,3,4-thiadiazole-2(3H)-thione
-
Sporosarcina pasteurii
5-(4-propoxyphenyl)-3-propyl-1,3,4-thiadiazole-2(3H)-thione
-
Sporosarcina pasteurii
5-benzhydryl-1,3,4-oxadiazole-2(3H)-thione pH 8.2, IC50: 0.95 mM Canavalia ensiformis
5-benzhydryl-1,3,4-oxadiazole-2(3H)-thione pH 8.2, IC50: 0.25 mM Proteus mirabilis
5-benzhydryl-1,3,4-oxadiazole-2(3H)-thione
-
Sporosarcina pasteurii
5-benzhydryl-1,3,4-thiadiazole-2(3H)-thione pH 8.2, IC50: below 0.125 mM Proteus mirabilis
5-benzhydryl-1,3,4-thiadiazole-2(3H)-thione
-
Sporosarcina pasteurii
5-benzyl-1,3,4-oxadiazole-2(3H)-thione pH 8.2, IC50: below 0.125 mM Proteus mirabilis
5-benzyl-1,3,4-oxadiazole-2(3H)-thione
-
Sporosarcina pasteurii
5-cyclohexyl-1,3,4-oxadiazole-2(3H)-thione pH 8.2, IC50: 0.124 mM Canavalia ensiformis
5-cyclohexyl-1,3,4-oxadiazole-2(3H)-thione pH 8.2, IC50: 0.125 mM Proteus mirabilis
5-cyclohexyl-1,3,4-oxadiazole-2(3H)-thione
-
Sporosarcina pasteurii
5-phenyl-1,3,4-oxadiazole-2(3H)-thione pH 8.2, IC50: below 0.125 mM Proteus mirabilis
5-phenyl-1,3,4-oxadiazole-2(3H)-thione
-
Sporosarcina pasteurii
5-phenyl-1,3,4-thiadiazole-2(3H)-thione pH 8.2, IC50: 0.29 mM Canavalia ensiformis
5-phenyl-1,3,4-thiadiazole-2(3H)-thione pH 8.2, IC50: 0.25 mM Proteus mirabilis
5-phenyl-1,3,4-thiadiazole-2(3H)-thione
-
Sporosarcina pasteurii
5-pyridin-4-yl-1,3,4-oxadiazole-2(3H)-thione pH 8.2, IC50: above 0.2 mM Canavalia ensiformis
5-pyridin-4-yl-1,3,4-oxadiazole-2(3H)-thione pH 8.2, IC50: below 0.125 mM Proteus mirabilis
5-pyridin-4-yl-1,3,4-oxadiazole-2(3H)-thione
-
Sporosarcina pasteurii
5-pyridin-4-yl-1,3,4-thiadiazole-2(3H)-thione pH 8.2, IC50: 0.124 mM Canavalia ensiformis
5-pyridin-4-yl-1,3,4-thiadiazole-2(3H)-thione pH 8.2, IC50: below 0.125 mM Proteus mirabilis
5-pyridin-4-yl-1,3,4-thiadiazole-2(3H)-thione
-
Sporosarcina pasteurii
5-[(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)methyl]-1,3,4-oxadiazole-2(3H)-thione pH 8.2, IC50: 0.095 mM Canavalia ensiformis
5-[(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)methyl]-1,3,4-oxadiazole-2(3H)-thione pH 8.2, IC50: 0.5 mM Proteus mirabilis
5-[(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)methyl]-1,3,4-oxadiazole-2(3H)-thione
-
Sporosarcina pasteurii
5-[(5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)methyl]-1,3,4-thiadiazole-2(3H)-thione pH 8.2, IC50: 0.095 mM Canavalia ensiformis
5-[(5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)methyl]-1,3,4-thiadiazole-2(3H)-thione pH 8.2, IC50: 0.5 mM Proteus mirabilis
5-[(5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)methyl]-1,3,4-thiadiazole-2(3H)-thione
-
Sporosarcina pasteurii
5-[3-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl]-1,3,4-oxadiazole-2(3H)-thione pH 8.2, IC50: 0.093 mM Canavalia ensiformis
5-[3-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl]-1,3,4-oxadiazole-2(3H)-thione pH 8.2, IC50: below 0.125 mM Proteus mirabilis
5-[3-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl]-1,3,4-oxadiazole-2(3H)-thione
-
Sporosarcina pasteurii
5-[3-(benzyloxy)phenyl]-1,3,4-oxadiazole-2(3H)-thione
-
Sporosarcina pasteurii
5-[4-(benzyloxy)phenyl]-1,3,4-oxadiazole-2(3H)-thione pH 8.2, IC50: 0.41 mM Canavalia ensiformis
5-[4-(benzyloxy)phenyl]-1,3,4-oxadiazole-2(3H)-thione pH 8.2, IC50: 0.5 mM Proteus mirabilis
5-[4-(benzyloxy)phenyl]-1,3,4-oxadiazole-2(3H)-thione
-
Sporosarcina pasteurii
5-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3H-[1,3,4]oxadiazole-2-thione pH 8.2, IC50: 0.244 mM Canavalia ensiformis
5-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3H-[1,3,4]oxadiazole-2-thione
-
Sporosarcina pasteurii
5-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3H-[1,3,4]thiadiazole-2-thione
-
Sporosarcina pasteurii

Organism

Organism UniProt Comment Textmining
Canavalia ensiformis
-
-
-
Proteus mirabilis
-
-
-
Sporosarcina pasteurii
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
urea + H2O
-
Sporosarcina pasteurii CO2 + 2 NH3
-
?

Synonyms

Synonyms Comment Organism
BPU
-
Sporosarcina pasteurii
JBU
-
Canavalia ensiformis
PMU
-
Proteus mirabilis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.002
-
2,2'-bi-1,3,4-thiadiazole-5,5'(4H,4'H)-dithione pH 5.0, 30°C Sporosarcina pasteurii
0.002
-
5-(4-hydroxyphenyl)-1,3,4-thiadiazole-2(3H)-thione pH 5.0, 30°C Sporosarcina pasteurii
0.002
-
5-(4-hydroxyphenyl)-1,3,4-thiadiazole-2(3H)-thione pH 8.2, 30°C Sporosarcina pasteurii
0.005
-
5-[(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)methyl]-1,3,4-oxadiazole-2(3H)-thione pH 5.0, 30°C Sporosarcina pasteurii
0.005
-
5-[(5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)methyl]-1,3,4-thiadiazole-2(3H)-thione pH 5.0, 30°C Sporosarcina pasteurii
0.005
-
5-[(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)methyl]-1,3,4-oxadiazole-2(3H)-thione pH 8.2, 30°C Sporosarcina pasteurii
0.005
-
2,2'-bi-1,3,4-thiadiazole-5,5'(4H,4'H)-dithione pH 8.2, 30°C Sporosarcina pasteurii
0.006
-
5-[3-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl]-1,3,4-oxadiazole-2(3H)-thione pH 5.0, 30°C Sporosarcina pasteurii
0.008
-
5-[(5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)methyl]-1,3,4-thiadiazole-2(3H)-thione pH 8.2, 30°C Sporosarcina pasteurii
0.01
-
5-[3-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl]-1,3,4-oxadiazole-2(3H)-thione pH 8.2, 30°C Sporosarcina pasteurii
0.02
-
2,2'-bi-1,3,4-oxadiazole-5,5'(4H,4'H)-dithione pH 5.0, 30°C Sporosarcina pasteurii
0.02
-
5-phenyl-1,3,4-thiadiazole-2(3H)-thione pH 5.0, 30°C Sporosarcina pasteurii
0.03
-
2,2'-bi-1,3,4-oxadiazole-5,5'(4H,4'H)-dithione pH 8.2, 30°C Sporosarcina pasteurii
0.04
-
5-benzhydryl-1,3,4-oxadiazole-2(3H)-thione pH 5.0, 30°C Sporosarcina pasteurii
0.04
-
4-(4-benzoyl-5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)phenyl benzoate pH 5.0, 30°C Sporosarcina pasteurii
0.05
-
5-(4-hydroxyphenyl)-1,3,4-oxadiazole-2(3H)-thione pH 5.0, 30°C Sporosarcina pasteurii
0.05
-
5-(4-hydroxyphenyl)-1,3,4-oxadiazole-2(3H)-thione pH 8.2, 30°C Sporosarcina pasteurii
0.06
-
5-benzhydryl-1,3,4-thiadiazole-2(3H)-thione pH 5.0, 30°C Sporosarcina pasteurii
0.06
-
5-(4-propoxyphenyl)-3-propyl-1,3,4-thiadiazole-2(3H)-thione pH 5.0, 30°C Sporosarcina pasteurii
0.09
-
5-pyridin-4-yl-1,3,4-oxadiazole-2(3H)-thione pH 5.0, 30°C Sporosarcina pasteurii
0.09
-
5-cyclohexyl-1,3,4-oxadiazole-2(3H)-thione pH 5.0, 30°C Sporosarcina pasteurii
0.09
-
5-pyridin-4-yl-1,3,4-oxadiazole-2(3H)-thione pH 8.2, 30°C Sporosarcina pasteurii
0.09
-
5-[3-(benzyloxy)phenyl]-1,3,4-oxadiazole-2(3H)-thione pH 8.2, 30°C Sporosarcina pasteurii
0.1
-
5-cyclohexyl-1,3,4-oxadiazole-2(3H)-thione pH 8.2, 30°C Sporosarcina pasteurii
0.1
-
5-phenyl-1,3,4-thiadiazole-2(3H)-thione pH 8.2, 30°C Sporosarcina pasteurii
0.11
-
5-pyridin-4-yl-1,3,4-thiadiazole-2(3H)-thione pH 5.0, 30°C Sporosarcina pasteurii
0.11
-
5-benzhydryl-1,3,4-oxadiazole-2(3H)-thione pH 8.2, 30°C Sporosarcina pasteurii
0.11
-
5-pyridin-4-yl-1,3,4-thiadiazole-2(3H)-thione pH 8.2, 30°C Sporosarcina pasteurii
0.12
-
5-benzhydryl-1,3,4-thiadiazole-2(3H)-thione pH 8.2, 30°C Sporosarcina pasteurii
0.13
-
5-(1-naphthyl)-1,3,4-oxadiazole-2(3H)-thione pH 5.0, 30°C Sporosarcina pasteurii
0.13
-
5-(1-naphthyl)-1,3,4-oxadiazole-2(3H)-thione pH 8.2, 30°C Sporosarcina pasteurii
0.14
-
5-benzyl-1,3,4-oxadiazole-2(3H)-thione pH 5.0, 30°C Sporosarcina pasteurii
0.15
-
5-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3H-[1,3,4]thiadiazole-2-thione pH 5.0, 30°C Sporosarcina pasteurii
0.15
-
5-(3-hydroxyphenyl)-1,3,4-oxadiazole-2(3H)-thione pH 8.2, 30°C Sporosarcina pasteurii
0.16
-
5-(3-hydroxyphenyl)-1,3,4-oxadiazole-2(3H)-thione pH 5.0, 30°C Sporosarcina pasteurii
0.16
-
5-[3-(benzyloxy)phenyl]-1,3,4-oxadiazole-2(3H)-thione pH 5.0, 30°C Sporosarcina pasteurii
0.16
-
5-phenyl-1,3,4-oxadiazole-2(3H)-thione pH 8.2, 30°C Sporosarcina pasteurii
0.17
-
5-benzyl-1,3,4-oxadiazole-2(3H)-thione pH 8.2, 30°C Sporosarcina pasteurii
0.19
-
5-phenyl-1,3,4-oxadiazole-2(3H)-thione pH 5.0, 30°C Sporosarcina pasteurii
0.19
-
5-(4-propoxyphenyl)-3-propyl-1,3,4-thiadiazole-2(3H)-thione pH 8.2, 30°C Sporosarcina pasteurii
0.2
-
4-amino-5-pyridin-4-yl-2,4-dihydro-3H-1,2,4-triazole-3-thione pH 8.2, 30°C Sporosarcina pasteurii
0.23
-
5-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3H-[1,3,4]oxadiazole-2-thione pH 5.0, 30°C Sporosarcina pasteurii
0.23
-
5-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3H-[1,3,4]oxadiazole-2-thione pH 8.2, 30°C Sporosarcina pasteurii
0.24
-
4-amino-5-pyridin-4-yl-2,4-dihydro-3H-1,2,4-triazole-3-thione pH 5.0, 30°C Sporosarcina pasteurii
0.25
-
5-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3H-[1,3,4]thiadiazole-2-thione pH 8.2, 30°C Sporosarcina pasteurii
0.29
-
4-amino-5-(4-hydroxyphenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione pH 8.2, 30°C Sporosarcina pasteurii
0.29
-
4-(4-benzoyl-5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)phenyl benzoate pH 8.2, 30°C Sporosarcina pasteurii
0.31
-
4-amino-5-(4-hydroxyphenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione pH 5.0, 30°C Sporosarcina pasteurii
0.69
-
5-[4-(benzyloxy)phenyl]-1,3,4-oxadiazole-2(3H)-thione pH 5.0, 30°C Sporosarcina pasteurii
0.85
-
5-[4-(benzyloxy)phenyl]-1,3,4-oxadiazole-2(3H)-thione pH 8.2, 30°C Sporosarcina pasteurii

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.093
-
pH 8.2, IC50: 0.093 mM Canavalia ensiformis 5-[3-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl]-1,3,4-oxadiazole-2(3H)-thione
0.095
-
pH 8.2, IC50: 0.095 mM Canavalia ensiformis 5-[(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)methyl]-1,3,4-oxadiazole-2(3H)-thione
0.095
-
pH 8.2, IC50: 0.095 mM Canavalia ensiformis 5-[(5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)methyl]-1,3,4-thiadiazole-2(3H)-thione
0.124
-
pH 8.2, IC50: 0.124 mM Canavalia ensiformis 5-cyclohexyl-1,3,4-oxadiazole-2(3H)-thione
0.124
-
pH 8.2, IC50: 0.124 mM Canavalia ensiformis 5-pyridin-4-yl-1,3,4-thiadiazole-2(3H)-thione
0.125
-
pH 8.2, IC50: 0.125 mM Proteus mirabilis 5-cyclohexyl-1,3,4-oxadiazole-2(3H)-thione
0.125
-
pH 8.2, IC50: below 0.125 mM Proteus mirabilis 5-(1-naphthyl)-1,3,4-oxadiazole-2(3H)-thione
0.125
-
pH 8.2, IC50: below 0.125 mM Proteus mirabilis 5-pyridin-4-yl-1,3,4-oxadiazole-2(3H)-thione
0.125
-
pH 8.2, IC50: below 0.125 mM Proteus mirabilis 2,2'-bi-1,3,4-oxadiazole-5,5'(4H,4'H)-dithione
0.125
-
pH 8.2, IC50: below 0.125 mM Proteus mirabilis 5-[3-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl]-1,3,4-oxadiazole-2(3H)-thione
0.125
-
pH 8.2, IC50: below 0.125 mM Proteus mirabilis 5-pyridin-4-yl-1,3,4-thiadiazole-2(3H)-thione
0.125
-
pH 8.2, IC50: below 0.125 mM Proteus mirabilis 4-amino-5-(4-hydroxyphenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione
0.125
-
pH 8.2, IC50: below 0.125 mM Proteus mirabilis 5-(3-hydroxyphenyl)-1,3,4-oxadiazole-2(3H)-thione
0.125
-
pH 8.2, IC50: below 0.125 mM Proteus mirabilis 5-benzyl-1,3,4-oxadiazole-2(3H)-thione
0.125
-
pH 8.2, IC50: below 0.125 mM Proteus mirabilis 5-phenyl-1,3,4-oxadiazole-2(3H)-thione
0.125
-
pH 8.2, IC50: below 0.125 mM Proteus mirabilis 5-benzhydryl-1,3,4-thiadiazole-2(3H)-thione
0.133
-
pH 8.2, IC50: 0.133 mM Canavalia ensiformis 2,2'-bi-1,3,4-oxadiazole-5,5'(4H,4'H)-dithione
0.163
-
pH 8.2, IC50: 0.163 mM Canavalia ensiformis 4-amino-5-pyridin-4-yl-2,4-dihydro-3H-1,2,4-triazole-3-thione
0.2
-
pH 8.2, IC50: above 0.2 mM Canavalia ensiformis 5-pyridin-4-yl-1,3,4-oxadiazole-2(3H)-thione
0.214
-
pH 8.2, IC50: 0.214 mM Canavalia ensiformis 5-(1-naphthyl)-1,3,4-oxadiazole-2(3H)-thione
0.234
-
pH 8.2, IC50: 0.234 mM Canavalia ensiformis 4-(4-benzoyl-5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)phenyl benzoate
0.244
-
pH 8.2, IC50: 0.244 mM Canavalia ensiformis 5-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3H-[1,3,4]oxadiazole-2-thione
0.25
-
pH 8.2, IC50: 0.25 mM Proteus mirabilis 5-benzhydryl-1,3,4-oxadiazole-2(3H)-thione
0.25
-
pH 8.2, IC50: 0.25 mM Proteus mirabilis 5-phenyl-1,3,4-thiadiazole-2(3H)-thione
0.29
-
pH 8.2, IC50: 0.29 mM Canavalia ensiformis 5-phenyl-1,3,4-thiadiazole-2(3H)-thione
0.41
-
pH 8.2, IC50: 0.41 mM Canavalia ensiformis 5-[4-(benzyloxy)phenyl]-1,3,4-oxadiazole-2(3H)-thione
0.5
-
pH 8.2, IC50: 0.5 mM Proteus mirabilis 5-[4-(benzyloxy)phenyl]-1,3,4-oxadiazole-2(3H)-thione
0.5
-
pH 8.2, IC50: 0.5 mM Proteus mirabilis 5-[(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)methyl]-1,3,4-oxadiazole-2(3H)-thione
0.5
-
pH 8.2, IC50: 0.5 mM Proteus mirabilis 5-[(5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)methyl]-1,3,4-thiadiazole-2(3H)-thione
0.5
-
pH 8.2, IC50: 0.5 mM Proteus mirabilis 5-(4-hydroxyphenyl)-1,3,4-oxadiazole-2(3H)-thione
0.5
-
pH 8.2, IC50: 0.5 mM Proteus mirabilis 2,2'-bi-1,3,4-thiadiazole-5,5'(4H,4'H)-dithione
0.95
-
pH 8.2, IC50: 0.95 mM Canavalia ensiformis 5-benzhydryl-1,3,4-oxadiazole-2(3H)-thione