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Literature summary for 3.5.1.48 extracted from

  • Manneh, V.A.; Blankenship, J.
    Inhibitor studies on the characteristics of the active site of rat liver N8-acetylspermidine deacetylase (1985), Proc. West. Pharmacol. Soc., 28, 255-258.
No PubMed abstract available
Search for more literature for 3.5.1.48

Inhibitors

Inhibitors Comment Organism Structure
5-Aminovaleric acid Ki: 4.1 mM Rattus sp.
Diethylmalonate Ki: 8 mM Rattus sp.
echothiopate non-competitive inhibition, Ki: 0.4 mM, i.e.ammonium, (2-mercaptoethyl)trimethyl-, S-ester with O,O-diethyl phosphorothioate Rattus sp.
EDTA Ki: 5 mM Rattus sp.
N-acetylputrescine Ki: 0.8 mM Rattus sp.
N-ethylmaleimide Ki: 0.86 mM Rattus sp.
N1-acetylspermidine Ki: 1.37 mM Rattus sp.

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.011
-
 N8-Acetylspermidine
-
 Rattus sp.

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus sp. 5829
-

Organism

Organism UniProt Comment Textmining
Rattus sp.
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus sp.
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N8-acetylspermidine + H2O
-
 Rattus sp. acetate + spermidine
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.4
-
 echothiopate non-competitive inhibition, i.e.ammonium, (2-mercaptoethyl)trimethyl-, S-ester with O,O-diethyl phosphorothioate Rattus sp.
0.8
-
 N-acetylputrescine
-
 Rattus sp.
1.37
-
 N1-acetylspermidine
-
 Rattus sp.
4.1
-
 5-Aminovaleric acid
-
 Rattus sp.
5
-
 EDTA
-
 Rattus sp.
8
-
 Diethylmalonate
-
 Rattus sp.