Literature summary for 3.5.1.4 extracted from

Yamano, Y.; Tsuboi, K.; Hozaki, Y.; Takahashi, K.; Jin, X.H.; Ueda, N.; Wada, A.
Lipophilic amines as potent inhibitors of N-acylethanolamine-hydrolyzing acid amidase (2012), Bioorg. Med. Chem., 20, 3658-3665.

Application

Application	Comment	Organism
drug development	the enzyme may be another attractive drug target	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism
2-(hexadecyloxy)ethanamine	70% inhibition at 0.1 mM	Rattus norvegicus
2-aminoethyl decanoate	11% inhibition at 0.1 mM	Rattus norvegicus
2-aminoethyl dodecanoate	26% inhibition at 0.1 mM	Rattus norvegicus
2-aminoethyl hexadecanoate	50% inhibition at 0.1 mM	Rattus norvegicus
2-aminoethyl tetradecanoate	54% inhibition at 0.1 mM	Rattus norvegicus
2-dodecyloxy-1-ethylamine	49% inhibition at 0.1 mM	Rattus norvegicus
2-tetradecyloxy-1-ethylamine	71% inhibition at 0.1 mM	Rattus norvegicus
3-aminopropyl decanoate	45% inhibition at 0.1 mM	Rattus norvegicus
3-aminopropyl dodecanoate	37% inhibition at 0.1 mM	Rattus norvegicus
3-aminopropyl hexadecanoate	52% inhibition at 0.1 mM	Rattus norvegicus
3-aminopropyl tetradecanoate	54% inhibition at 0.1 mM	Rattus norvegicus
3-dodecyloxy-1-propanamine	27% inhibition at 0.1 mM	Rattus norvegicus
3-hexadecyloxy-1-propanamine	16% inhibition at 0.1 mM	Rattus norvegicus
3-tetradecyloxy-1-propanamine	29% inhibition at 0.1 mM	Rattus norvegicus
dodecyl 2-aminoacetate	66% inhibition at 0.1 mM	Rattus norvegicus
dodecyl 3-aminopropanoate	27% inhibition at 0.1 mM	Rattus norvegicus
hexadecyl 2-aminoacetate	29% inhibition at 0.1 mM	Rattus norvegicus
hexadecylamine	-	Rattus norvegicus
hexadecyltrimethylammonium chloride	-	Rattus norvegicus
additional information	N-(2-oxo-3-oxetanyl)amide inhibitor synthesis and evaluation, overview. No inhibition by N-pentadecylcyclohexanecarboxamide	Rattus norvegicus
pentadecyl 2-aminoacetate	56% inhibition at 0.1 mM	Rattus norvegicus
pentadecyl 3-aminopropanoate	27% inhibition at 0.1 mM	Rattus norvegicus
pentadecylamine	-	Rattus norvegicus
tetradecyl 2-aminoacetate	84% inhibition at 0.1 mM	Rattus norvegicus
tetradecylamine	-	Rattus norvegicus
tridecyl 2-aminoacetate	89% inhibition at 0.1 mM	Rattus norvegicus
tridecyl 3-aminopropanoate	27% inhibition at 0.1 mM	Rattus norvegicus
undecylamine	-	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
lung	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
palmitoylethanolamide + H2O	-	Rattus norvegicus	palmitic acid + ethanolamine	-	?

Synonyms

Synonyms	Comment	Organism
N-acylethanolamine-hydrolyzing acid amidase	-	Rattus norvegicus
NAAA	-	Rattus norvegicus
NAE-hydrolyzing acid amidase	-	Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Rattus norvegicus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
5	-	assay at	Rattus norvegicus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0075	-	pH 5.0, 37°C	Rattus norvegicus	pentadecylamine
0.0118	-	pH 5.0, 37°C	Rattus norvegicus	tridecyl 2-aminoacetate