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Literature summary for 3.5.1.4 extracted from
- An unprecedented catalytic motif revealed in the model structure of amide hydrolyzing antibody 312D6 (2004), Chembiochem, 5, 129-131.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | amide hydrolyzing antibody 312D6 induces catalysis by transition-state mimicry and torsional activation, and accelerates the hydrolysis of amides by a factor of 1000, overview | Human immunodeficiency virus 1 |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Human immunodeficiency virus 1 | - |
i.e. HIV1 | - |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| a monocarboxylic acid amide + H2O = a monocarboxylate + NH3 | catalytic role of an arginine dyad, the catalytic motif is revealed in the model structure of amide hydrolyzing antibody 312D6, the antibody induces catalysis by transition-state mimicry and torsional activation, and accelerates the hydrolysis of amides by a factor of 1000, overview | Human immunodeficiency virus 1 |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the Fv dimer was constructed by using the crystallographic structure of antibody 25.3, PDB 1AFV, as a template, activity of the amide hydrolyzing antibody 312D6 with sulfonamide hapten substrates, complex formation and structure, antibody 312d6 is highly specific for p-tolylsubstituted indole sulfonamides and carboxamides, docking analysis, overview | Human immunodeficiency virus 1 | ? | - |
? |  |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 9 | - |
Human immunodeficiency virus 1 |
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Release 2023.1 (January 2023)
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