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Literature summary for 3.5.1.4 extracted from

  • Vandevoorde, S.; Fowler, C.J.
    Inhibition of fatty acid amide hydrolase and monoacylglycerol lipase by the anandamide uptake inhibitor VDM11: evidence that VDM11 acts as an FAAH substrate (2005), Br. J. Pharmacol., 145, 885-893.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
(5Z,8Z,11Z,14Z)-eicosantetraenoic acid 3-thienyl methyl ester i.e. CAY-10402 Rattus norvegicus
3'-carbamoyl-biphenyl-3-yl-cyclohexylcarbamate i.e. URB597, specific Rattus norvegicus
N-(4-hydroxy-2-methylphenyl)arachidonylamide i.e. VDM11, an anandamide uptake inhibitor, IC50 is 0.0026 mM, inhibitory potency depends upon the concentration of bovine serum albumin Rattus norvegicus
N-(4-hydroxyphenyl)arachidonylamide i.e. AM404, an anandamide uptake inhibitor, IC50 is 0.0021 mM Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Rattus norvegicus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
anandamide + H2O Rattus norvegicus i.e. arachidonoylethanolamide ?
-
?
anandamide + H2O Rattus norvegicus Sprague-Dawley i.e. arachidonoylethanolamide ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
Sprague-Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
cerebellum
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
anandamide + H2O i.e. arachidonoylethanolamide Rattus norvegicus ?
-
?
anandamide + H2O i.e. arachidonoylethanolamide or AEA Rattus norvegicus ?
-
?
anandamide + H2O i.e. arachidonoylethanolamide Rattus norvegicus Sprague-Dawley ?
-
?
anandamide + H2O i.e. arachidonoylethanolamide or AEA Rattus norvegicus Sprague-Dawley ?
-
?
N-(4-hydroxy-2-methylphenyl)arachidonylamide + H2O i.e. VDM11, 15-20% of the activity with anandamide Rattus norvegicus 4-amino-3-cresol + arachidonic acid
-
?
N-(4-hydroxy-2-methylphenyl)arachidonylamide + H2O i.e. VDM11, 15-20% of the activity with anandamide Rattus norvegicus Sprague-Dawley 4-amino-3-cresol + arachidonic acid
-
?
N-(4-hydroxyphenyl)arachidonylamide + H2O i.e. AM404 Rattus norvegicus 4-aminophenol + arachidonic acid
-
?

Synonyms

Synonyms Comment Organism
FAAH
-
Rattus norvegicus
fatty acid amide hydrolase
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
assay at Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0021
-
i.e. AM404, an anandamide uptake inhibitor, IC50 is 0.0021 mM Rattus norvegicus N-(4-hydroxyphenyl)arachidonylamide
0.0026
-
i.e. VDM11, an anandamide uptake inhibitor, IC50 is 0.0026 mM, inhibitory potency depends upon the concentration of bovine serum albumin Rattus norvegicus N-(4-hydroxy-2-methylphenyl)arachidonylamide