Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.5.1.28 extracted from

  • Frankel, M.B.; Hendrickx, A.P.; Missiakas, D.M.; Schneewind, O.
    LytN, a murein hydrolase in the cross-wall compartment of Staphylococcus aureus, is involved in proper bacterial growth and envelope assembly (2011), J. Biol. Chem., 286, 32593-32605.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.1.28

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Staphylococcus aureus

Localization

Localization Comment Organism GeneOntology No. Textmining
envelope
-
 Staphylococcus aureus 31975
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
peptidoglycan + H2O Staphylococcus aureus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA Sepharose column chromatography, gel filtration Staphylococcus aureus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
peptidoglycan + H2O
-
 Staphylococcus aureus ?
-
 ?

Synonyms

Synonyms Comment Organism
LytN LytN harbors LysM and histidine-dependent amidohydrolase/peptidase domains, the latter of which functions as both an N-acetylmuramoyl-L-alanine amidase and D-alanyl-glycine endopeptidase Staphylococcus aureus

General Information

General Information Comment Organism
physiological function LytN secretion into the cross-wall promotes peptidoglycan separation and completion of the staphylococcal cell cycle. LytN is required for proper staphylococcal growth. Overexpression of LytN triggers lysis of the staphylococcal cross-wall Staphylococcus aureus