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Literature summary for 3.5.1.26 extracted from

  • Tikkanen, R.; Riikonen, A.; Oinonen, C.; Rouvinen, J.; Peltonen, L.
    Functional analyses of active site residues of human lysosomal aspartylglucosaminidase: implications for catalytic mechanism and autocatalytic activation (1996), EMBO J., 15, 2954-2960.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.1.26

Cloned(Commentary)

Cloned (Comment) Organism
expression in COS cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
R234A nearly complete decrease of activity, misprocessing of precursor in ER Homo sapiens
R234L nearly complete decrease of activity, misprocessing of precursor in ER Homo sapiens
R234Q nearly complete decrease of activity, misprocessing of precursor in ER Homo sapiens
T224A nearly complete decrease of activity Homo sapiens
T224S nearly complete decrease of activity Homo sapiens
T257A nearly complete decrease of activity Homo sapiens
T257A nearly complete decrease of activity, misprocessing of precursor in ER Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5
-
 N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O Homo sapiens involved in degradation of glycoproteins 2-acetamido-1-amino-1,2-dideoxy-beta-D-glucose + L-aspartate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
to homogeneity, chromatography techniques Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
leukocyte
-
 Homo sapiens
-
placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O involved in degradation of glycoproteins Homo sapiens 2-acetamido-1-amino-1,2-dideoxy-beta-D-glucose + L-aspartate
-
 ?