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Literature summary for 3.5.1.24 extracted from

  • Yadav, R.; Singh, P.K.; Puniya, A.K.; Shukla, P.
    Catalytic Interactions and molecular docking of bile salt hydrolase (BSH) from L. plantarum RYPR1 and its prebiotic utilization (2016), Front. Microbiol., 7, 2116 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.1.24

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glycocholic acid + H2O Lactiplantibacillus plantarum
-
 cholate + glycine
-
 ?
glycocholic acid + H2O Lactiplantibacillus plantarum RYPR1
-
 cholate + glycine
-
 ?
taurocholic acid + H2O Lactiplantibacillus plantarum
-
 cholate + taurine
-
 ?
taurocholic acid + H2O Lactiplantibacillus plantarum RYPR1
-
 cholate + taurine
-
 ?

Organism

Organism UniProt Comment Textmining
Lactiplantibacillus plantarum B9V401
-
-
Lactiplantibacillus plantarum RYPR1 B9V401
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glycocholic acid + H2O
-
 Lactiplantibacillus plantarum cholate + glycine
-
 ?
glycocholic acid + H2O
-
 Lactiplantibacillus plantarum RYPR1 cholate + glycine
-
 ?
taurocholic acid + H2O
-
 Lactiplantibacillus plantarum cholate + taurine
-
 ?
taurocholic acid + H2O
-
 Lactiplantibacillus plantarum RYPR1 cholate + taurine
-
 ?

Synonyms

Synonyms Comment Organism
bile salt hydrolase
-
 Lactiplantibacillus plantarum
BSH
-
 Lactiplantibacillus plantarum

General Information

General Information Comment Organism
physiological function bile salt hydrolase (BSH) is an enzyme that catalyses the deconjugation of bile salt. Lactobacillus plantarum RYPR1 is analyzed upon prebiotic utilization (with commercially available prebiotics lactulose, inulin, xylitol, raffinose, and oligofructose P95), catalytic interactions, and molecular docking with taurocholic and glycocholic acid. Residues Asn12, Ile8, and Leu6 interact with substrate taurocholic acid, and Lys88 and Asp126 interact with glycocholic acid. Molecular dynamics simulations, analysis of dynamic protein stability Lactiplantibacillus plantarum