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Literature summary for 3.5.1.24 extracted from

  • Wang, G.; Huang, W.; Xia, Y.; Xiong, Z.; Ai, L.
    Cholesterol-lowering potentials of Lactobacillus strain overexpression of bile salt hydrolase on high cholesterol diet-induced hypercholesterolemic mice (2019), Food Funct., 10, 1684-1695 .
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
gene bsh1, recombinant overexpression in enzyme-deficient Lactobacillus casei LC2W, the transformed strain is termed Lactobacillus casei pWQH01, quantitative real-time PCR gene expression analysis Lactiplantibacillus plantarum

Organism

Organism UniProt Comment Textmining
Lactiplantibacillus plantarum
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Lactiplantibacillus plantarum AR113
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no activity in Lactobacillus casei strain LC2W
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Source Tissue

Source Tissue Comment Organism Textmining

Synonyms

Synonyms Comment Organism
bile salt hydrolase
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 Lactiplantibacillus plantarum
BSH
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 Lactiplantibacillus plantarum
BSH1
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 Lactiplantibacillus plantarum

General Information

General Information Comment Organism
malfunction mechanisms underlying the effects of Lactobacillus overexpression of bile salt hydrolase in hypercholesterolemia. The liver mRNA levels of farnesoid X receptor (FXR) and small heterodimer partner (SHP) are significantly downregulated in the AR113 and pWQH01 groups compared to the high-cholesterol diet (HCD) and enzyme-lacking LC2W groups, whereas the mRNA expression of hepatic cholesterol 7alpha-hydroxylase (CYP7A1), liver X receptor (LXR) and low density lipoprotein receptor (LDLR) is significantly upregulated in the AR113 (wild-type, high activity) and pWQH01 (recombinant overexpressing) groups compared to the HCD group Lactiplantibacillus plantarum
physiological function the enzyme exerts a cholesterol-reducing effect in vivo in the host, male C57BL/6J mice. Also the recombinant strain Lactobacillus casei pWQH01 overexpressing the enzyme from Lactobacillus plantarum strain AR113 shows a cholesterol-reducing effect in vivo in the host, both with a phenotype of reduced body weight. Effects of probiotics on the expression of key genes involved in bile acid and cholesterol metabolism in hypercholesterolemic mice, detailed overview Lactiplantibacillus plantarum